Biomedical Microdevices

, Volume 12, Issue 5, pp 949–957

An on-chip whole blood/plasma separator with bead-packed microchannel on COC polymer

Article

DOI: 10.1007/s10544-010-9449-7

Cite this article as:
Shim, J.S., Browne, A.W. & Ahn, C.H. Biomed Microdevices (2010) 12: 949. doi:10.1007/s10544-010-9449-7

Abstract

A disposable on-chip whole blood/plasma separator, which is able to separate plasma from whole human blood by capillary force through a bead-packed microchannel, has been designed, fabricated and characterized in this work. Various sizes of silica beads were slurry-packed through a microchannel using a bump structure which held beads in a defined region. The bead-packed microchannel induces a capillary force which allows plasma to move forward through the bead-packed column more rapidly than red blood cells (RBCs). The blood/plasma separator with bead-packed microchannel has successfully separated plasma from the whole blood without haemolysis of RBCs. The separation method developed in this work can be applied to various on-chip stationary filtrations of RBC for point-of-care clinical diagnostics.

Keywords

Bead-packed microchannelBlood/plasma separatorOn-chip filtrationLab on a chipSlurry-packed microcolumn

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Joon S. Shim
    • 1
  • Andrew W. Browne
    • 1
  • Chong H. Ahn
    • 1
  1. 1.Microsystems and BioMEMS Laboratory, Department of Electrical and Computer EngineeringUniversity of CincinnatiCincinnatiUSA