Article

Biomedical Microdevices

, Volume 12, Issue 5, pp 949-957

An on-chip whole blood/plasma separator with bead-packed microchannel on COC polymer

  • Joon S. ShimAffiliated withMicrosystems and BioMEMS Laboratory, Department of Electrical and Computer Engineering, University of Cincinnati
  • , Andrew W. BrowneAffiliated withMicrosystems and BioMEMS Laboratory, Department of Electrical and Computer Engineering, University of Cincinnati
  • , Chong H. AhnAffiliated withMicrosystems and BioMEMS Laboratory, Department of Electrical and Computer Engineering, University of Cincinnati Email author 

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Abstract

A disposable on-chip whole blood/plasma separator, which is able to separate plasma from whole human blood by capillary force through a bead-packed microchannel, has been designed, fabricated and characterized in this work. Various sizes of silica beads were slurry-packed through a microchannel using a bump structure which held beads in a defined region. The bead-packed microchannel induces a capillary force which allows plasma to move forward through the bead-packed column more rapidly than red blood cells (RBCs). The blood/plasma separator with bead-packed microchannel has successfully separated plasma from the whole blood without haemolysis of RBCs. The separation method developed in this work can be applied to various on-chip stationary filtrations of RBC for point-of-care clinical diagnostics.

Keywords

Bead-packed microchannel Blood/plasma separator On-chip filtration Lab on a chip Slurry-packed microcolumn