Abstract
A drug delivery system that consists of microperforated polyimide microtubes was developed and characterized. Two groups of polyimide tubes were used. One set consisted of microtubes (I.D. = 125 μm) with 32.9 ± 1.7 μm size holes. The second set consisted of larger tubes (I.D. = 1000 μm) with 362–542 μm holes. The number of holes was varied between 1 and 3. The small tubes were loaded with crystal violet (CV) and ethinyl estradiol (EE) and the drug release studies were performed in 0.01 M phosphate buffered saline (PBS) (pH 7.1–7.4) at 37.0 ± 1.0°C for upto 4 weeks. The large tubes were loaded with CV and the drug release was studied in vitro in PBS and also ex vivo in rabbit’s vitreous humor. Linear release rates with R2 > 0.9900 were obtained for all groups with CV and EE. Release rates of 7.8 ± 2.5, 16.2 ± 5.5, and 22.5 ± 6.0 ng/day for CV and 30.1 ± 5.8 ng/day for EE were obtained for small tubes. For large tubes, a release rate of 10.8 ± 4.1, 15.8 ± 4.8 and 22.1 ± 6.7 μg/day was observed in vitro in PBS and a release rate of 5.8 ± 1.8 μg/day was observed ex vivo in vitreous humor.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
AbraxisKits. http://www.abraxiskits.com/moreinfo/PN590051USER.pdf Accessed on Jun 05 2009
C. Berde, S. Nurko, N. Engl. J. Med. 358(22), 2400–2402 (2008)
I.H. Black, J. McManus, Prehosp. Emerg. Care 13(2), 223–227 (2009)
O.A. Boubriak, J.P. Urban, S. Akhtar, K.M. Meek, A.J. Bron, Exp. Eye Res. 71(5), 503–514 (2000)
M.R. Bragulat, M.L. Abarca, M.T. Bruguera, F.J. Cabanes, Appl. Environ. Microbiol. 57(9), 2777–2780 (1991)
A.N. Edward, N.J. Abbott, L. Drewes, Q.R. Smith, P. Couraud, E.A. Chiocca, K.L. Audus, N.H. Greig, N.D. Doolittle, Neurosurgery 44(3), 604–608 (1999)
L.A. Geddes, R. Roeder, Ann. Biomed. Eng. 31(7), 879–890 (2003)
J. Hsu, Curr. Opin. Ophthalmol. 18(3), 235–239 (2007)
X. Huang, C.S. Brazel, J. Control Release 73(2–3), 121–136 (2001)
H. Kawakami, T. Kanamori, S. Kubota, J. Artif. Organs 6(2), 124–129 (2003)
J.H. Kempen, S. Gangaputra, E. Daniel, G.A. Levy-Clarke, R.B. Nussenblatt, J.T. Rosenbaum, E.B. Suhler, J.E. Thorne, C.S. Foster, D.A. Jabs, K.J. Helzlsouer, Am. J. Ophthalmol. 146(6), 802–812 e801 (2008)
Y. Li, K. Itoh, W. Watanabe, K. Yamada, D. Kuroda, J. Nishii, Y. Jiang, Opt. Lett. 26(23), 1912–1914 (2001)
S. Linder, H. Baltes, F. Gnaedinger, E. Doering, in Proceedings of IEEE The Ninth Annual International Workshop on Micro Electro Mechanical Systems (San Diego, CA, USA, 1996), pp. 38–43
K.L. Macoul, D. Pavan-Langston, Arch. Ophthalmol. 93(8), 587–590 (1975)
J.D. Markman, A. Philip, Anesthesiol. Clin. 25(4), 883–898 (2007). viii
Merck-Index, The Merck Index. White House Station, New Jersey, (Merck & Co., Inc., White House Station, New Jersey, 2006)
M. Niwa, H. Kawakami, M. Kanno, S. Nagaoka, T. Kanamori, T. Shinbo, S. Kubota, J. Biomater. Sci. Polym. Ed. 12(5), 533–542 (2001)
B.D. Ratner, A.S. Hoffman, F.J. Schoen, J.E. Lemons, Biomaterial Science: An Introduction to Materials in Medicine London (Elsivier Academic, London, 2004)
D.V. Reddy, V.E. Kinsey, Arch. Ophthalmol. 63, 715–720 (1960)
J.R. Robinson, V.H.L. Lee, Controlled Drug Delivery. Fundamentals and Applications. New York (Marcel Dekker, New York, 1987)
I. Safarik, M. Safarikova, Water Res. 36(1), 196–200 (2002)
M. Safarikova, I. Safarik, Eur. Cells Mater. 3(Suppl 2), 192–195 (2002)
S.J. Segal, Stud. Fam. Plann. 14(6–7), 159–163 (1983)
M.M. Shaaban, S.I. Elwan, M.Y. el-Kabsh, S.A. Farghaly, N. Thabet, Contraception 30(5), 421–430 (1984)
D. Shi, Biomedical devices and their applications New York (Springer, New York, 2004)
B. Steffansen, P. Ashton, A. Buur, Int. J. Pharm. 132, 243–250 (1996)
T. Stover, G. Paasche, T. Lenarz, T. Ripken, P. Breitenfeld, H. Lubatschowski, T. Fabian, Cochlear Implants Int. 8(1), 38–52 (2007)
J. Swarbrick, J.C. Boylan, Encyclopedia of Pharmaceutical Technology. New York (Marcel Dekker, New York, 2002)
A. Urtti, Adv. Drug Deliv. Rev. 58(11), 1131–1135 (2006)
Varian-Inc. http://www.varianinc.com/cgi-bin/nav?products/dissolution/testers/varian400 ds&cid = KNHMOHJMFL Accessed on July 27 2009
Y. Zhou, X.Y. Wu, J. Control Release 90(1), 23–36 (2003)
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Rastogi, A., Luo, Z., Wu, Z. et al. Development and characterization of a scalable microperforated device capable of long-term zero order drug release. Biomed Microdevices 12, 915–921 (2010). https://doi.org/10.1007/s10544-010-9446-x
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10544-010-9446-x