Article

Biomedical Microdevices

, Volume 12, Issue 1, pp 169-177

Fabrication of monodisperse, large-sized, functional biopolymeric microspheres using a low-cost and facile microfluidic device

  • Liping ZhuAffiliated withState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University
  • , Yaogang LiAffiliated withState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University
  • , Qinghong ZhangAffiliated withState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University
  • , Hongzhi WangAffiliated withState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University Email author 
  • , Meifang ZhuAffiliated withState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University Email author 

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Abstract

We report a novel and facile method for fabricating coaxial microfluidic devices processing various dimensions at low cost, in which polypropylene hollow fibers or glass capillaries are used as the tip of the dispersed phase injection tube. With this coaxial microfluidic device, monodisperse biocompatible microspheres ranging from 300 to 800 μm were obtained by collecting oil-in-water or water-in-oil emulsions and solidifying the suspended microspheres. Microsphere size could be controlled by changing the tips or tuning the concentrations of the dispersed and continuous phases. By adding functional nanoparticles into the dispersed phase, it was demonstrated that fluorescent and magnetic microspheres can be fabricated easily using these microfluidic devices.

Keywords

Biomaterial Functional Monodisperse Microfluidic device Microspheres Large-sized