Article

Biomedical Microdevices

, Volume 11, Issue 6, pp 1309-1315

3D microfabricated bioreactor with capillaries

  • Chunguang XiaAffiliated withDepartment of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign
  • , Nicholas X. FangAffiliated withDepartment of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign Email author 

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Abstract

We present in this paper the implementation of an innovative three dimensional (3D) microfabrication technology coupled with numerical simulation to enhance the mass transport in 3D cell culture. The core of this microfabrication technology is a high-resolution projection micro stereolithography (PμSL) using a spatial light modulator as a dynamic mask which enables a parallel fabrication of highly complex 3D microstructures. In this work, a set of poly (ethylene glycol) microfabricated bioreactors are demonstrated with PμSL technology. We observed both experimentally and numerically the regulation of metabolism and the growth of yeast cells by controlling the density of micro-capillaries. Further development of these 3D microfabricated bioreactors is expected to provide artificially constructed tissues for clinical applications.

Keywords

3D microfabrication Bioreactor Transport Modeling Vascular