Article

Biomedical Microdevices

, Volume 11, Issue 6, pp 1251-1257

A monolithic polymeric microdevice for pH-responsive drug delivery

  • Jian ChenAffiliated withInstitute of Biomaterials and Biomedical Engineering, University of Toronto
  • , Michael ChuAffiliated withDepartment of Pharmaceutical Sciences, University of Toronto
  • , Khajag KoulajianAffiliated withDepartment of Physiology, University of Toronto
  • , Xiao Yu WuAffiliated withDepartment of Pharmaceutical Sciences, University of Toronto
  • , Adria GiaccaAffiliated withDepartment of Physiology, University of Toronto
  • , Yu SunAffiliated withInstitute of Biomaterials and Biomedical Engineering, University of Toronto Email author 

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Abstract

A drug-delivery microdevice integrating pH-responsive nano-hydrogel particles functioning as intelligent nano valves is described. The polymeric microdevices are monolithic without requiring peripheral control hardware or additional components for controlling drug-release rates. pH-responsive nanoparticles were synthesized and embedded into a composite membrane. The resulting pH-responsive composite membranes were integrated with PDMS micro reservoirs via a room-temperature transfer bonding technique to form the proof-of-concept microdevices. In vitro release characterization of the microdevices was conducted in which the release rate of Vitamin B12 (VB12) as a model drug increased dramatically when the local pH value was decreased from 7.4 to 4. This device concept can serve as a platform technology for intelligent drug delivery in response to various in vivo environmental signals.

Keywords

Controlled drug delivery Microdevices pH-responsive hydrogel Nano hydrogel particles