Article

Biomedical Microdevices

, Volume 10, Issue 2, pp 131-140

Alginate and chitosan particles as drug delivery system for cell therapy

  • Gianni CiofaniAffiliated withCRIM Lab–Center for Research in Microengineering, Scuola Superiore Sant’AnnaCRIM–Center for Research In Microengineering, Scuola Superiore Sant’Anna Email author 
  • , Vittoria RaffaAffiliated withCRIM Lab–Center for Research in Microengineering, Scuola Superiore Sant’Anna
  • , Arianna MenciassiAffiliated withCRIM Lab–Center for Research in Microengineering, Scuola Superiore Sant’AnnaItalian Institute of Technology (IIT Network)
  • , Paolo DarioAffiliated withCRIM Lab–Center for Research in Microengineering, Scuola Superiore Sant’AnnaItalian Institute of Technology (IIT Network)

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Abstract

Drug-carrying microstructures which have a size similar to biological structures are very attractive to encapsulate drugs and protect them during the transit in the human body. This paper describes polymeric (alginate and chitosan) particles (average radius 500 nm) produced by homogenization techniques. In vitro studies performed on cell lines demonstrate the effectiveness of such particles for intracellular drug delivery. Our experiments suggest that cellular up - take increases linearly with particle concentration in the growth medium, and the internalization process has a first order kinetics (characteristic time around 0.5 h−1). In addition, the particles degrade within 24 h from the up-take without side effects for cell viability.

Keywords

Drug delivery system Alginate particles Chitosan particles Cellular up-take