Biomedical Microdevices

, Volume 9, Issue 6, pp 787–794

Ultrananocrystalline diamond film as an optimal cell interface for biomedical applications

  • Piyush Bajaj
  • Demir Akin
  • Amit Gupta
  • Debby Sherman
  • Bing Shi
  • Orlando Auciello
  • Rashid Bashir
Article

DOI: 10.1007/s10544-007-9090-2

Cite this article as:
Bajaj, P., Akin, D., Gupta, A. et al. Biomed Microdevices (2007) 9: 787. doi:10.1007/s10544-007-9090-2

Abstract

Surfaces of materials that promote cell adhesion, proliferation, and growth are critical for new generation of implantable biomedical devices. These films should be able to coat complex geometrical shapes very conformally, with smooth surfaces to produce hermetic bioinert protective coatings, or to provide surfaces for cell grafting through appropriate functionalization. Upon performing a survey of desirable properties such as chemical inertness, low friction coefficient, high wear resistance, and a high Young’s modulus, diamond films emerge as very attractive candidates for coatings for biomedical devices. A promising novel material is ultrananocrystalline diamond (UNCD®) in thin film form, since UNCD possesses the desirable properties of diamond and can be deposited as a very smooth, conformal coating using chemical vapor deposition. In this paper, we compared cell adhesion, proliferation, and growth on UNCD films, silicon, and platinum films substrates using different cell lines. Our results showed that UNCD films exhibited superior characteristics including cell number, total cell area, and cell spreading. The results could be attributed to the nanostructured nature or a combination of nanostructure/surface chemistry of UNCD, which provides a high surface energy, hence promoting adhesion between the receptors on the cell surface and the UNCD films.

Keywords

Ultrananocrystalline diamondMEMSBioMEMSBiocompatibilityNanomaterialUNCD

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Piyush Bajaj
    • 1
    • 2
  • Demir Akin
    • 1
    • 2
  • Amit Gupta
    • 7
  • Debby Sherman
    • 4
  • Bing Shi
    • 5
  • Orlando Auciello
    • 5
    • 6
  • Rashid Bashir
    • 1
    • 2
    • 3
  1. 1.Birck Nanotechnology Center, Bindley Biosciences CenterPurdue UniversityWest LafayetteUSA
  2. 2.Weldon School of Biomedical EngineeringPurdue UniversityWest LafayetteUSA
  3. 3.School of Electrical and Computer EngineeringPurdue UniversityWest LafayetteUSA
  4. 4.Electron Microscopy Facility, Department of BiologyPurdue UniversityWest LafayetteUSA
  5. 5.Materials Science DivisionArgonne National LaboratoryArgonneUSA
  6. 6.Center for Nanoscale MaterialsArgonne National LaboratoryArgonneUSA
  7. 7.BioMEMS Resource CenterMassachusetts General HospitalCambridgeUSA