Biology & Philosophy

, Volume 27, Issue 6, pp 785–810

Cancer cells and adaptive explanations

Authors

    • Università degli Studi di Milano, European Institute of Oncology (IEO)
Article

DOI: 10.1007/s10539-012-9334-2

Cite this article as:
Germain, P. Biol Philos (2012) 27: 785. doi:10.1007/s10539-012-9334-2

Abstract

The aim of this paper is to assess the relevance of somatic evolution by natural selection to our understanding of cancer development. I do so in two steps. In the first part of the paper, I ask to what extent cancer cells meet the formal requirements for evolution by natural selection, relying on Godfrey-Smith’s (Darwinian populations and natural selection. Oxford University Press, Oxford, 2009) framework of Darwinian populations. I argue that although they meet the minimal requirements for natural selection, cancer cells are not paradigmatic Darwinian populations. In the second part of the paper, I examine the most important examples of adaptation in cancer cells. I argue that they are not significant accumulations of evolutionary changes, and that as a consequence natural selection plays a lesser role in their explanation. Their explanation, I argue, is best sought in the previously existing wiring of the healthy cells.

Keywords

CancerAdaptationNatural selectionExplanationDarwinian populations

Copyright information

© Springer Science+Business Media B.V. 2012