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The characterization of anti-T. cruzi activity relationships between ferrocenyl, cyrhetrenyl complexes and ROS release

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Abstract

Trypanosoma cruzi (T. cruzi) is the parasite that causes Chagas disease. Nifurtimox is the most used drug against the T. cruzi, this drug increases intermediaries nitro group, being mainly responsible for the high toxicity component, for this reason it is important to study new organic compounds and thus improve therapeutic strategies against Chagas disease. The electronic effects of ferrocenyl and cyrhetrenyl fragments were investigated by DFT calculation. A close correlation was found between HOMO–LUMO gap of nitro radical NO 2 with the experimental reduction potential found for nitro group and IC50 of two forms the T. cruzi (epimastigote and trypomastigote). The IC50 on human hepatoma cells is higher for both compounds compared to IC50 demonstrated in the two forms the T. cruzi, and additionally show reactive oxygen species release. The information obtained in this paper could generate two new drugs with anti-T. cruzi activity, but additional studies are needed.

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Abbreviations

ROS:

Reactive oxygen species

T. cruzi :

Trypanosoma cruzi

HepG2:

Human hepatoma cells

NFX:

Nifurtimox

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All authors have given approval to the final version of the manuscript.

Funding

This work was supported by the research grants from Fondo Nacional de Desarrollo Científico y Tecnológico—Fondecyt 11130007 (R.R-T.), 3140448 (C.E.), 1121078 (F.S.), 1120286 (R.A.), Millennium Institute on Immunology and Immunotherapy P09-016-F (F.S.) and UNAB DI-741-15/N (F.S.).

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Correspondence to Rodrigo Ramirez-Tagle.

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Echeverría, C., Romero, V., Arancibia, R. et al. The characterization of anti-T. cruzi activity relationships between ferrocenyl, cyrhetrenyl complexes and ROS release. Biometals 29, 743–749 (2016). https://doi.org/10.1007/s10534-016-9953-1

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  • DOI: https://doi.org/10.1007/s10534-016-9953-1

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