BioMetals

, Volume 26, Issue 6, pp 1013–1021

Developmental neurotoxicity of cadmium on enzyme activities of crucial offspring rat brain regions

Authors

  • Vasileios Stolakis
    • Laboratory of Pharmacology, Medical SchoolNational and Kapodistrian University of Athens
    • Laboratory of Physiology, Medical SchoolNational and Kapodistrian University of Athens
    • Laboratory of Physiology, Medical SchoolNational and Kapodistrian University of Athens
  • Konstantinos Kalafatakis
    • Laboratory of Pharmacology, Medical SchoolNational and Kapodistrian University of Athens
    • Laboratory of Physiology, Medical SchoolNational and Kapodistrian University of Athens
  • Apostolos Zarros
    • Laboratory of Physiology, Medical SchoolNational and Kapodistrian University of Athens
  • Nikolina Skandali
    • Laboratory of Pharmacology, Medical SchoolNational and Kapodistrian University of Athens
    • Laboratory of Physiology, Medical SchoolNational and Kapodistrian University of Athens
  • Vasiliki Gkanti
    • Laboratory of Pharmacology, Medical SchoolNational and Kapodistrian University of Athens
    • Laboratory of Physiology, Medical SchoolNational and Kapodistrian University of Athens
  • Argyro Kyriakaki
    • Laboratory of Pharmacology, Medical SchoolNational and Kapodistrian University of Athens
    • Laboratory of Pharmacology, Medical SchoolNational and Kapodistrian University of Athens
Article

DOI: 10.1007/s10534-013-9678-3

Cite this article as:
Stolakis, V., Tsakiris, S., Kalafatakis, K. et al. Biometals (2013) 26: 1013. doi:10.1007/s10534-013-9678-3

Abstract

Cadmium (Cd) is an environmental contaminant known to exert significant neurotoxic effects on both humans and experimental animals. The aim of this study was to shed more light on the effects of gestational (in utero) and lactational maternal exposure to Cd (50 ppm of Cd as Cd-chloride in the drinking water) on crucial brain enzyme activities in important rat offspring brain regions (frontal cortex, hippocampus, hypothalamus, pons and cerebellum). Our study provides a brain region-specific view of the changes in the activities of three crucial brain enzymes as a result of the developmental neurotoxicity of Cd. Maternal exposure to Cd during both gestation and lactation results into significant changes in the activities of acetylcholinesterase and Na+,K+-ATPase in the frontal cortex and the cerebellum of the offspring rats, as well as in a significant increase in the hippocampal Mg2+-ATPase activity. These brain-region-specific findings underline the need for further research in the field of Cd-induced developmental neurotoxicity. Deeper understanding of the mechanisms underlying the neurodevelopmental deficits taking place due to in utero and early age exposure to Cd could shed more light on the causes of its well-established cognitive implications.

Keywords

Cadmium Acetylcholinesterase Na+,K+-ATPase Mg2+-ATPase Rat Frontal cortex Hippocampus Cerebellum

Copyright information

© Springer Science+Business Media New York 2013