Article

BioMetals

, Volume 26, Issue 6, pp 1013-1021

Developmental neurotoxicity of cadmium on enzyme activities of crucial offspring rat brain regions

  • Vasileios StolakisAffiliated withLaboratory of Pharmacology, Medical School, National and Kapodistrian University of AthensLaboratory of Physiology, Medical School, National and Kapodistrian University of Athens
  • , Stylianos TsakirisAffiliated withLaboratory of Physiology, Medical School, National and Kapodistrian University of Athens Email author 
  • , Konstantinos KalafatakisAffiliated withLaboratory of Pharmacology, Medical School, National and Kapodistrian University of AthensLaboratory of Physiology, Medical School, National and Kapodistrian University of Athens
  • , Apostolos ZarrosAffiliated withLaboratory of Physiology, Medical School, National and Kapodistrian University of Athens
  • , Nikolina SkandaliAffiliated withLaboratory of Pharmacology, Medical School, National and Kapodistrian University of AthensLaboratory of Physiology, Medical School, National and Kapodistrian University of Athens
  • , Vasiliki GkantiAffiliated withLaboratory of Pharmacology, Medical School, National and Kapodistrian University of AthensLaboratory of Physiology, Medical School, National and Kapodistrian University of Athens
  • , Argyro KyriakakiAffiliated withLaboratory of Pharmacology, Medical School, National and Kapodistrian University of Athens
  • , Charis LiapiAffiliated withLaboratory of Pharmacology, Medical School, National and Kapodistrian University of Athens Email author 

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Abstract

Cadmium (Cd) is an environmental contaminant known to exert significant neurotoxic effects on both humans and experimental animals. The aim of this study was to shed more light on the effects of gestational (in utero) and lactational maternal exposure to Cd (50 ppm of Cd as Cd-chloride in the drinking water) on crucial brain enzyme activities in important rat offspring brain regions (frontal cortex, hippocampus, hypothalamus, pons and cerebellum). Our study provides a brain region-specific view of the changes in the activities of three crucial brain enzymes as a result of the developmental neurotoxicity of Cd. Maternal exposure to Cd during both gestation and lactation results into significant changes in the activities of acetylcholinesterase and Na+,K+-ATPase in the frontal cortex and the cerebellum of the offspring rats, as well as in a significant increase in the hippocampal Mg2+-ATPase activity. These brain-region-specific findings underline the need for further research in the field of Cd-induced developmental neurotoxicity. Deeper understanding of the mechanisms underlying the neurodevelopmental deficits taking place due to in utero and early age exposure to Cd could shed more light on the causes of its well-established cognitive implications.

Keywords

Cadmium Acetylcholinesterase Na+,K+-ATPase Mg2+-ATPase Rat Frontal cortex Hippocampus Cerebellum