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Biocatalysis and biotransformation of resveratrol in microorganisms

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Abstract

Resveratrol, a major stilbene phytoalexin, is a valuable polyphenol that has been recognized for its benefits to human health. Resveratrol has antioxidant and antitumor effects and promotes longevity. It is used in medicine, health care products, cosmetics, and other industries. Therefore, a sustainable source for resveratrol production is required. This review describes the metabolic engineering of microorganisms, the biotransformation and biosynthesis of endophytes and the oxidation or degradation of resveratrol. We compare various available methods for resveratrol production, and summarize the practical challenges facing the microbial production of resveratrol. The future research direction for resveratrol is also discussed.

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Acknowledgments

Thanks for financial supports from the National Natural Science Foundation of China (Project No. 41306139); the National Science Foundation for Talents Training in Basic Science, China (J1103507); a PhD Programs Foundation of Ministry of Education of China (Grant No. 20133207120001), the Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions.

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  1. Jiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Industrialization of Microbial Resources, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, Jiangsu Province, China

    Yan-Zhen Mei, Ruo-Xue Liu, Dong-Peng Wang, Xia Wang & Chuan-Chao Dai

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  1. Yan-Zhen Mei
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  2. Ruo-Xue Liu
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  3. Dong-Peng Wang
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  4. Xia Wang
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Correspondence to Chuan-Chao Dai.

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Mei, YZ., Liu, RX., Wang, DP. et al. Biocatalysis and biotransformation of resveratrol in microorganisms. Biotechnol Lett 37, 9–18 (2015). https://doi.org/10.1007/s10529-014-1651-x

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