, Volume 28, Issue 23, pp 1909-1912
Date: 26 Sep 2006

Enzymatic synthesis of (R )-cyanohydrins by a novel (R )-oxynitrilase from Vicia sativa L.

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The defatted seed meal of common vetch (Vicia sativa L.) served as a source of (R)-oxynitrilase which catalyzed the enantioselective addition of HCN to aromatic, heteroaromatic, fluoro-substituted aromatic aldehydes to produce the corresponding enantiomeric pure cyanohydrins in yields of 52–100% and 88–99% ee at 12°C under micro-aqueous medium (diisopropyl ether) without addition of buffer solution.