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Anti-hepatitis B activities of ganoderic acid from Ganoderma lucidum

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Abstract

Ganoderic acid, from Ganoderma lucidum, at 8 µg/ml inhibited replication of hepatitis B virus (HBV) in HepG2215 cells over 8 days. Production of HBV surface antigen and HBV e antigen were 20 and 44% of controls without ganoderic acid. Male KM mice were significantly protected from liver injury, induced with carbon tetrachloride, by treatment with ganoderic acid at 10 mg and 30 mg/kg·d (by intravenous injection) 7 days. Ganoderic acid at the same dosage also significantly protected the mice from liver injury induced by M. bovis BCG plus lipopolysaccharide (from Escherichia coli 0127:B8).

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Authors and Affiliations

  1. College of Life Science, South China Normal University, Guangzhou, 510631, P.R. China

    Yan-Qun Li

  2. Jiangxi Academy of Science, Nanchang, 330029, P.R. China

    Shun-Fa Wang

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  1. Yan-Qun Li
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  2. Shun-Fa Wang
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Correspondence to Yan-Qun Li.

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Li, YQ., Wang, SF. Anti-hepatitis B activities of ganoderic acid from Ganoderma lucidum . Biotechnol Lett 28, 837–841 (2006). https://doi.org/10.1007/s10529-006-9007-9

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  • DOI: https://doi.org/10.1007/s10529-006-9007-9

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