Abstract
A high percentage of critical patients are found to develop acute respiratory distress syndrome (ARDS). Several studies have reported high mortality rates in these cases which are most frequently associated with multiple organ dysfunctions syndrome. Lately, many efforts have been made to evaluate and monitor ARDS in critical patients. In this regard, the assessment of genetic polymorphisms responsible for developing ARDS present as a challenge and are considered future biomarkers. Early detection of the specific polymorphic gene responsible for ARDS in critically ill patients can prove to be a useful tool in the future, able to help decrease the mortality rates in these cases. Moreover, identifying the genetic polymorphism in these patients can help in the implementation of a personalized intensive therapy scheme for every type of patient, based on its genotype.
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Abbreviations
- ARDS:
-
Acute respiratory distress syndrome
- MODS:
-
Multiple organ dysfunction syndrome
- ICU:
-
Intensive care unit
- VEGF:
-
Vascular endothelial growth factor
- SIRS:
-
Systemic inflammatory response syndrome
- IL-8:
-
Interleukin 8
- BALF:
-
Bronchoalveolar lavage fluid
- IL-1β:
-
Interleukin 1 beta
- ENA-78:
-
Epithelial cell neutrophil activator 78
- MIP-1α:
-
Macrophage inflammatory peptide-1 alpha
- TNF-α:
-
Tumor necrosis factor alpha
- LPS:
-
Lipopolysaccharide
- HMGB1:
-
High mobility group box 1
- PECAM-1:
-
Platelet entothelial cell adhesion molecule-1
- MBL:
-
Mannose binding lectin
- HO-1:
-
Heme-oxygenase-1
- PC:
-
Activated protein C
- TM:
-
Thrombomodulin
- EPCR:
-
Endothelial protein C receptor
- HIF-1α:
-
Hypoxia-inducible factor 1 alpha
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Horhat, F.G., Gundogdu, F., David, L.V. et al. Early Evaluation and Monitoring of Critical Patients with Acute Respiratory Distress Syndrome (ARDS) Using Specific Genetic Polymorphisms. Biochem Genet 55, 204–211 (2017). https://doi.org/10.1007/s10528-016-9787-0
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DOI: https://doi.org/10.1007/s10528-016-9787-0