Biomedical Engineering

, Volume 47, Issue 2, pp 61–64

Determination of Threshold Energy Level of Monopolar Defibrillation Pulses Using the Luo–Rudy Cardiomyocyte Model

  • V. A. Vostrikov
  • B. B. Gorbunov
  • A. N. Gusev
  • S. V. Selishchev
Article

DOI: 10.1007/s10527-013-9335-8

Cite this article as:
Vostrikov, V.A., Gorbunov, B.B., Gusev, A.N. et al. Biomed Eng (2013) 47: 61. doi:10.1007/s10527-013-9335-8

The effect of defibrillation pulses of different waveforms on the Luo–Rudy cardiomyocyte model in the Cell Electrophysiology Simulation Environment (CESE) was comparatively tested. It was established that a half-sine pulse has the minimum threshold of cell excitation energy, while an exponential pulse exhibits the maximum threshold (22% increase in comparison with the half-sine pulse). The threshold energy of the trapezoidal pulse with sloped rising and falling (waveform of the first phase of bipolar pulse in imPulse AND-P automated external defibrillators at energy levels of 150 and 180 J) was only slightly (4%) higher than the threshold energy of the half-sine pulse. The threshold energy of truncated exponential pulses, which are widely used in modern defibrillators, exceeded the threshold energy of the half-sine pulse by 10-14% (depending on the decline value). These results obtained with the Luo–Rudy model differ significantly from the results obtained using the characteristic energy method with the Blair model.

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • V. A. Vostrikov
    • 1
  • B. B. Gorbunov
    • 2
  • A. N. Gusev
    • 2
  • S. V. Selishchev
    • 2
  1. 1.Sechenov Moscow State Medical UniversityMoscowRussia
  2. 2.National Research University of Electronic Technology, ZelenogradMoscowRussia