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Resistance to prooxidant agent paraquat in the short- and long-lived lines of the seed beetle (Acanthoscelides obtectus)

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Abstract

In the present study we test whether variation in resistance to paraquat (PQ), a free radical generator, correlates with variation in longevity in two sets of seed beetles (Acanthoscelides obtectus) experimental lines that were selected either for early reproduction and short-life or late reproduction and long-life. Long-lived late reproduction lines (L) showed increased resistance to PQ, while opposite was true for short-lived early reproduction line (E). Striking outcome of the selection for early and late reproduction in A. obtectus is asymmetry of responses to alternate mating schedules. The intensity of response depended on selection regime, sex and PQ dose. Evolution of longevity and PQ resistance was faster in L than E selection regime, and in females than males. To understand how age-specific mortality rates are affected by PQ we decomposed post-stress mortality data (using Gompertz mortality model) into initial mortality rate, which reflects basal vulnerability to stresses and age-specific mortality rate, which concerns the rate of increase in stress vulnerability, i.e. the rate of senescence. By estimating the parameters of the Gompertz mortality model we have shown that longevity reduction caused by PQ was the consequence of the increased baseline mortality rather than a speed up of the rate of ageing.

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Acknowledgments

This work was supported by Serbian Ministry of Education, Science and Technological Development Grant No. 173007. The manuscript reviewer provided valuable input for the revision of the manuscript.

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Authors and Affiliations

  1. Institute for Biological Research, University of Belgrade, Despot Stefan Blvd. 142, 11060, Belgrade, Serbia

    Jelica Lazarević, Mirko Đorđević, Biljana Stojković & Nikola Tucić

  2. Faculty of Biology, University of Belgrade, Studentski Trg 3, 11000, Belgrade, Serbia

    Biljana Stojković

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  1. Jelica Lazarević
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  2. Mirko Đorđević
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  3. Biljana Stojković
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  4. Nikola Tucić
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Correspondence to Jelica Lazarević.

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Lazarević, J., Đorđević, M., Stojković, B. et al. Resistance to prooxidant agent paraquat in the short- and long-lived lines of the seed beetle (Acanthoscelides obtectus). Biogerontology 14, 141–152 (2013). https://doi.org/10.1007/s10522-013-9417-8

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