Behavior Genetics

, 36:845

Heritability and Reliability of P300, P50 and Duration Mismatch Negativity

Authors

    • Social, Genetic Developmental Psychiatry Research Centre, Institute of PsychiatryKing’s College London
    • Division of Psychological Medicine, Institute of PsychiatryKing’s College London
  • Katja Schulze
    • Division of Psychological Medicine, Institute of PsychiatryKing’s College London
  • Frühling Rijsdijk
    • Social, Genetic Developmental Psychiatry Research Centre, Institute of PsychiatryKing’s College London
  • Marco Picchioni
    • Division of Psychological Medicine, Institute of PsychiatryKing’s College London
  • Ulrich Ettinger
    • Neuroimaging Research Group, Institute of PsychiatryKing’s College London
  • Elvira Bramon
    • Division of Psychological Medicine, Institute of PsychiatryKing’s College London
  • Robert Freedman
    • Departments of Psychiatry and PharmacologyUniversity of Colorado Health Sciences Center
  • Robin M. Murray
    • Division of Psychological Medicine, Institute of PsychiatryKing’s College London
  • Pak Sham
    • Social, Genetic Developmental Psychiatry Research Centre, Institute of PsychiatryKing’s College London
    • Department of PsychiatryUniversity of Hong Kong
Original Paper

DOI: 10.1007/s10519-006-9091-6

Cite this article as:
Hall, M.H., Schulze, K., Rijsdijk, F. et al. Behav Genet (2006) 36: 845. doi:10.1007/s10519-006-9091-6

Abstract

Background

Event-related potentials (ERPs) have been suggested as possible endophenotypes of schizophrenia. We investigated the test–retest reliabilities and heritabilities of three ERP components in healthy monozygotic and dizygotic twin pairs.

Methods

ERP components (P300, P50 and MMN) were recorded using a 19-channel electroencephalogram (EEG) in 40 healthy monozygotic twin pairs, 19 of them on two separate occasions, and 30 dizygotic twin pairs. Zygosity was determined using DNA genotyping.

Results

High reliabilities were found for the P300 amplitude and its latency, MMN amplitude, and P50 suppression ratio components. Intra-class correlation (ICC) = 0.86 and 0.88 for the P300 amplitude and P300 latency respectively. Reliability of MMN peak amplitude and mean amplitude were 0.67 and 0.66 respectively. P50 T/C ratio reliability was 0.66. Model fitting analyses indicated a substantial heritability or familial component of variance for these ERP measures. Heritability estimates were 63 and 68% for MMN peak amplitude and mean amplitude respectively. For P50 T/C ratio, 68% heritability was estimated. P300 amplitude heritability was estimated at 69%, and while a significant familiality effect was found for P300 latency there was insufficient power to distinguish between shared environment and genetic factors.

Conclusions

The high reliability and heritability of the P300 amplitude, MMN amplitude, and P50 suppression ratio components supports their use as candidate endophenotypes for psychiatric research.

Keywords

Reliability ERPs Twins Genetic analysis Heritability

Copyright information

© Springer Science+Business Media, Inc. 2006