Behavior Genetics

, Volume 36, Issue 4, pp 567–576

The Implications of Simultaneous Smoking Initiation for Inferences about the Genetics of Smoking Behavior from Twin Data

  • Michele L. Pergadia
  • Andrew C. Heath
  • Arpana Agrawal
  • Kathleen K. Bucholz
  • Nicholas G. Martin
  • Pamela A. F. Madden
Article

DOI: 10.1007/s10519-005-9042-7

Cite this article as:
Pergadia, M.L., Heath, A.C., Agrawal, A. et al. Behav Genet (2006) 36: 567. doi:10.1007/s10519-005-9042-7

Abstract

We examined early social influences across stages of smoking within the context of a twin study using an environmental exposure specific to smoking: whether twins started smoking at the same time (“simultaneous smoking initiation”: SSI). We expected that SSI would be a good index of shared social influences on smoking initiation. Rates of SSI were indeed significantly higher in MZ twins and in twins who shared peers and classes, as well as in male twins. With the exception of regular smoking in females, we found no significant difference in estimates of genetic and environmental parameters between SSI and non-SSI pairs for any of the smoking measures that we examined (DSM-IV and Fagerstrom HSI measures of nicotine dependence; DSM-IV nicotine withdrawal; heavy smoking; and in males, regular smoking). For regular smoking in females, allowing for additional shared environmental influences associated with SSI only modestly reduced our estimates of additive genetic variance (56% vs. 68%). These results indicate the important social influences that may occur for smoking initiation do not appear to seriously bias estimates of genetic effects on later stages of smoking.

Key words:

Environmental influencesgenetic influencessimultaneous smoking initiationtwin data

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Michele L. Pergadia
    • 1
    • 3
  • Andrew C. Heath
    • 1
  • Arpana Agrawal
    • 1
  • Kathleen K. Bucholz
    • 1
  • Nicholas G. Martin
    • 2
  • Pamela A. F. Madden
    • 1
  1. 1.Department of PsychiatryWashington University School of MedicineSt. LouisUSA
  2. 2.Queensland Institute of Medical ResearchBrisbaneAustralia
  3. 3.Department of PsychiatryWashington University School of MedicineSt. LouisUSA