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Effect of Afobazole and Betaine on Cognitive Disorders in the Offspring of Rats with Streptozotocin-Induced Diabetes and Their Relationship with DNA Damage

  • PHARMACOLOGY AND TOXICOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

Cognitive activity in 60-day-old offspring of rats (intrauterine development in experimental streptozotocin-induced diabetes) was studied on the model of food-seeking behavior under conditions of free choice in a 6-arm maze. The formation of the food-procuring skill was significantly delayed, which attests to impairment of cognitive functions in these animals. Peroral administration of afobazole (10 and 50 mg/kg) and betaine (50 and 100 mg/kg) significantly and dose-dependently alleviated this disorder. Correlation analysis of the data on delayed formation of a food-procuring skill and results of DNA comet attests to a strong relationship between DNA damage in cells of the embryo and placenta during intrauterine development and cognitive dysfunction in the postnatal offspring of animals with streptozotocin-induced diabetes.

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Authors and Affiliations

  1. V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia

    V. V. Zabrodina, O. V. Shreder, E. D. Shreder & A. D. Durnev

Authors
  1. V. V. Zabrodina
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  2. O. V. Shreder
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  3. E. D. Shreder
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  4. A. D. Durnev
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Corresponding author

Correspondence to V. V. Zabrodina.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 161, No. 3, pp. 335-342, March, 2016

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Zabrodina, V.V., Shreder, O.V., Shreder, E.D. et al. Effect of Afobazole and Betaine on Cognitive Disorders in the Offspring of Rats with Streptozotocin-Induced Diabetes and Their Relationship with DNA Damage. Bull Exp Biol Med 161, 359–366 (2016). https://doi.org/10.1007/s10517-016-3414-2

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  • DOI: https://doi.org/10.1007/s10517-016-3414-2

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