Skip to main content
Log in

Cardiomyocyte Autophagia and Morphological Alterations in the Left Ventricular Myocardium during Acute Focal Ischemia

Bulletin of Experimental Biology and Medicine Aims and scope

In experiments on rabbits we evaluated the intensity of cardiomyocyte autophagia by the level beclin-1 protein and morphology of the left ventricular myocardium on days 1, 3, and 5 after the onset of focal ischemia caused by ligation of the descending branch of the left coronary artery. The morphological alterations in the left ventricular myocardium were accompanied by intensification of cardiomyocyte autophagia, which attained maximum on postligation day 1.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. A. B. Pupyshev, Tsitologiya, 56, No. 3, 179-196 (2014).

    CAS  Google Scholar 

  2. A. Abbate, C. Morales, M. De Falco, et al., Int. J. Cardiol., 121, No. 1, 109-111 (2007).

    Article  PubMed  Google Scholar 

  3. D. Gozuacik and A. Kimchi, Oncogene, 23, No. 16, 2891-2906 (2004).

    Article  PubMed  CAS  Google Scholar 

  4. C. He and D. J. Klionsky, Annu. Rev. Genet., 43, 67-93 (2009).

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  5. A. J. Meijer and P. Codogno, Int. J. Biochem. Cell Biol., 36, No. 12, 2445-2462 (2004).

    Article  PubMed  CAS  Google Scholar 

  6. H. Kanamori, G. Takemura, K. Goto, et al., Am. J. Physiol. Heart Circ. Physiol., 300, No. 6, H2261-H2271. (2011).

    Article  PubMed  CAS  Google Scholar 

  7. G. Kroemer, G. Marino, and B. Levine, Mol. Cell., 40, No. 2, 280-293 (2010).

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  8. B. Ravikumar, S. Sarkar, J. E. Davies, et al., Physiol. Rev. 90, No. 4, 1383-1435 (2010).

    Article  PubMed  CAS  Google Scholar 

  9. A. A. Sabe, N. Y. Elmadhun, R. S. Dalal, et al., J. Thorac. Cardiovasc. Surg., 147, No. 2, 792-798 (2014).

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  10. L. Yan, D. E. Vatner, S. J. Kim, et al., Proc. Natl Acad. Sci. USA, 102, No. 39, 13807-13812 (2005).

    Article  PubMed  CAS  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to M. L. Blagonravov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 9, pp. 389-391, September, 2015

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Blagonravov, M.L., Korshunova, A.Y., Azova, M.M. et al. Cardiomyocyte Autophagia and Morphological Alterations in the Left Ventricular Myocardium during Acute Focal Ischemia. Bull Exp Biol Med 160, 398–400 (2016). https://doi.org/10.1007/s10517-016-3180-1

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-016-3180-1

Key Words

Navigation