Bulletin of Experimental Biology and Medicine

, Volume 158, Issue 5, pp 638–640

Serum Levels of Neurosteroids in Patients with Affective Disorders

  • L. A. Levchuk
  • N. M. Vyalova
  • S. A. Ivanova
  • G. G. Simutkin
  • E. V. Lebedeva
  • N. A. Bokhan
Article

DOI: 10.1007/s10517-015-2825-9

Cite this article as:
Levchuk, L.A., Vyalova, N.M., Ivanova, S.A. et al. Bull Exp Biol Med (2015) 158: 638. doi:10.1007/s10517-015-2825-9
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According modern biological hypotheses of the pathogenesis of affective disorders, hypothalamic–pituitary–adrenal axis dysfunction play a special role in the pathogenesis of this condition. Our study shows that the range of neuroprotective neurosteroids is gender- and nosology-dependent. Patients with affective disorders have reduced levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate; the most pronounced defi ciency of neuroprotective neurosteroids is typical of patients with a single depressive episode. Reduced levels of neurosteroids producing an anabolic effect probably indicate depletion of adaptive capacities of the hypothalamic–pituitary–adrenal system in affective disorders.

Key Words

affective disordersdehydroepiandrosteronedehydroepiandrosterone sulfate

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • L. A. Levchuk
    • 1
  • N. M. Vyalova
    • 1
  • S. A. Ivanova
    • 1
  • G. G. Simutkin
    • 1
  • E. V. Lebedeva
    • 1
  • N. A. Bokhan
    • 1
    • 2
  1. 1.Mental Health Research InstituteSiberian Division of Russian Academy of Medical SciencesTomskRussia
  2. 2.National Research Tomsk State UniversityTomskRussia