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Role of Interleukin-18 in Destabilization of the Atherosclerotic Plaque in Humans

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Bulletin of Experimental Biology and Medicine Aims and scope

Precise location of IL-18 in cell and tissue elements of the atherosclerotic lesions in humans and its role in destabilization of the atherosclerotic plaque were detected. The data suggested a hypothesis on indirect involvement of IL-18 in destruction of the elastic and collagen fibers in an unstable plaque due to this cytokine capacity to induce the production of IFN-γ in T cells and macrophages, this eventually leading to inhibition of collagen and elastin synthesis in smooth muscle cells of the vascular wall and to loosening of the plaque cap.

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Authors and Affiliations

  1. Department of Common and Special Morphology, Institute of Experimental Medicine, North Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia

    P. V. Pigarevskii, S. V. Maltseva, V. A. Snegova & N. G. Davydova

Authors
  1. P. V. Pigarevskii
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  2. S. V. Maltseva
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  3. V. A. Snegova
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  4. N. G. Davydova
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Corresponding author

Correspondence to P. V. Pigarevskii.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 6, pp. 796–800, June, 2014

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Pigarevskii, P.V., Maltseva, S.V., Snegova, V.A. et al. Role of Interleukin-18 in Destabilization of the Atherosclerotic Plaque in Humans. Bull Exp Biol Med 157, 821–824 (2014). https://doi.org/10.1007/s10517-014-2675-x

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  • DOI: https://doi.org/10.1007/s10517-014-2675-x

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