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Involvement of NF-κB-Dependent Signaling and p38 MAPK Signaling Pathway in the Regulation of Hemopoiesis during Restrain Stress

  • General Pathology and Pathophysiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Protein kinase p38 was shown to contribute to the increase in production of granulocyte CSF by microenvironmental cells under conditions of restraint stress. Stimulation of colony-forming activity was not accompanied by the increase in maturation of clonogenic structures in the bone marrow granulocytic stem. This process was realized with the involvement of NF-κB-dependent signaling and p38 MAPK signaling pathway. Our study showed that the p38 MAPK signaling pathway plays an important role in the regulation of granulocytopoiesis, but not of erythropoiesis.

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Correspondence to A. M. Dygai.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 5, pp. 557-561, May, 2014

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Dygai, A.M., Zhdanov, V.V., Zyuz’kov, G.N. et al. Involvement of NF-κB-Dependent Signaling and p38 MAPK Signaling Pathway in the Regulation of Hemopoiesis during Restrain Stress. Bull Exp Biol Med 157, 548–551 (2014). https://doi.org/10.1007/s10517-014-2611-0

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  • DOI: https://doi.org/10.1007/s10517-014-2611-0

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