Protein kinase p38 was shown to contribute to the increase in production of granulocyte CSF by microenvironmental cells under conditions of restraint stress. Stimulation of colony-forming activity was not accompanied by the increase in maturation of clonogenic structures in the bone marrow granulocytic stem. This process was realized with the involvement of NF-κB-dependent signaling and p38 MAPK signaling pathway. Our study showed that the p38 MAPK signaling pathway plays an important role in the regulation of granulocytopoiesis, but not of erythropoiesis.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 5, pp. 557-561, May, 2014
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Dygai, A.M., Zhdanov, V.V., Zyuz’kov, G.N. et al. Involvement of NF-κB-Dependent Signaling and p38 MAPK Signaling Pathway in the Regulation of Hemopoiesis during Restrain Stress. Bull Exp Biol Med 157, 548–551 (2014). https://doi.org/10.1007/s10517-014-2611-0
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DOI: https://doi.org/10.1007/s10517-014-2611-0