Male rats were exposed to single or repeated (19 days) cold treatment (4°C) and non-cold stress (60-min shaking on a laboratory shuttle device). Retabolil had a hypotensive effect, which was accompanied by the prevention of a stress-induced increase in the concentration of a hypertensive hormone aldosterone. Under conditions of repeated stress, these effects were realized via μ-opioid receptors. Our results suggest that retabolil can be used as a hypotensive and aldosterone-blocking agent, at least during stress exposure in animals (and probably in humans).
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References
L. A. Leshchinskii, V. G. Lazarenko, and I. A. Shinkareva, Kardiologiya, 16, No. 1, 48-53 (1976).
T. A. Obut, Androgens in Adaptation of the Body: Biological Signifi cance of Adrenal Androgens [in Russian], Novosibirsk (2004).
T. A. Obut, Byull. Sib. Otd. Ros. Akad. Med. Nauk, 14, No. 2, 62-68 (1994).
M. V. Ovsyukova and T. A. Obut, Physiological Effects of Dehydroepiandrosterone Sulfate via μ-Opioid Receptors [in Russian], Novosibirsk (2011).
T. A. Obut, E. T. Obut, and A. L. Markel’, Patent RF No. 2142802, Hypotensive Drug, Byull. Izobret., No. 9 (December 20, 1999).
R. G. Segal’, E. I. Zharov, and P. M. Savenkov, Kardiologiya, 10, No. 2, 24-30 (1970).
P. O. Cover and J. C. Buckingham, J. Endocrinol., 121, No. 2, 213-220 (1989).
R. Francesconi and M. Mager, Experientia, 39, No. 6, 581-583 (1983).
E. M. Freel and J. M. C. Connell, J. Am. Soc. Nephrol., 15, No. 8, 1993-2001 (2004).
K. Hiramatsu, T. Yamada, and M. Katakura, Clin. Exp. Pharmacol. Physiol., 11, No. 2, 171-179 (1984).
N. Maninger, O. M. Wolkowitz, V. I. Reus, et al., Front. Neuroendocrinol., 30, No. 1, 65-91 (2009).
O. T. Wolf and C. Kirshbaum, Brain Res. Brain Res. Rev., 30, No. 3, 264-288 (1999).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 2, pp. 194-197, February, 2014
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Obut, T.A., Ovsyukova, M.V., Egorova, S.A. et al. Hypotensive Effect of Retabolil Correcting the Concentration of Aldosterone during Stress Exposures. Bull Exp Biol Med 157, 231–233 (2014). https://doi.org/10.1007/s10517-014-2532-y
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DOI: https://doi.org/10.1007/s10517-014-2532-y