Clastogenic and anticlastogenic activity of glucocorticoid hormones hydrocortisone, prednisolone, and dexamethasone was studied by counting chromosome aberrations in Crepis capillaris test system. Hydrocortisone in a concentration of 12.5 mg/ml produced a clastogenic effect and increased the number of chromosome aberrations in comparison with spontaneous level. Hydrocortisone (6.25 and 3.13 mg/ml), prednisolone (15, 7.5, and 3.75 mg/ml), and dexamethasone (1, 0.5, 0.25, and 0.125 mg/ml) exhibited an anticlastogenic effect and reduced ethyl methanesulfonate-induced mutagenesis.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 155, No. 1, pp. 86-88, January, 2013
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Koshpaeva, E.S., Semenov, V.V. Clastogenic and Anticlastogenic Activity of Glucocorticoid Hormones Hydrocortisone and Its Synthetic Analogs Prednisolone and Dexamethasone. Bull Exp Biol Med 155, 78–80 (2013). https://doi.org/10.1007/s10517-013-2084-6
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DOI: https://doi.org/10.1007/s10517-013-2084-6