Bulletin of Experimental Biology and Medicine

, Volume 154, Issue 5, pp 594–596

Analysis of the Application of MMP-9 Inhibitor in Skin Melanoma: Experimental Study

General Pathology and Pathophysiology

DOI: 10.1007/s10517-013-2007-6

Cite this article as:
Aksenenko, M.B. & Ruksha, T.G. Bull Exp Biol Med (2013) 154: 594. doi:10.1007/s10517-013-2007-6

Experiment on C57Bl/6 mice with modeled skin melanoma showed that selective inhibition of matrix metalloproteinase-9 increased lifetime and reduced the number of PCNA+ tumor cells and intensity of neoangiogenesis. Inhibition of matrix metalloproteinase-9 prevented tumor necrosis. The results suggest that matrix metalloproteinase-9 is involved not only in the regulation of extracellular matrix degradation, but also in the processes of cell proliferation and neoangiogenesis in skin melanoma. Therefore, this enzyme can be considered as a potential therapeutic target.

Key Words

matrix metalloproteinase-9skin melanomaneoangiogenesis

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Prof. V. V. Ivanov Department of Pathological Physiology with the Course of Clinical Pathophysiology, Prof. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical UniversityMoscowRussia