Analysis of the Application of MMP-9 Inhibitor in Skin Melanoma: Experimental Study
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- Aksenenko, M.B. & Ruksha, T.G. Bull Exp Biol Med (2013) 154: 594. doi:10.1007/s10517-013-2007-6
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Experiment on C57Bl/6 mice with modeled skin melanoma showed that selective inhibition of matrix metalloproteinase-9 increased lifetime and reduced the number of PCNA+ tumor cells and intensity of neoangiogenesis. Inhibition of matrix metalloproteinase-9 prevented tumor necrosis. The results suggest that matrix metalloproteinase-9 is involved not only in the regulation of extracellular matrix degradation, but also in the processes of cell proliferation and neoangiogenesis in skin melanoma. Therefore, this enzyme can be considered as a potential therapeutic target.