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Analysis of the Application of MMP-9 Inhibitor in Skin Melanoma: Experimental Study

  • General Pathology and Pathophysiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Experiment on C57Bl/6 mice with modeled skin melanoma showed that selective inhibition of matrix metalloproteinase-9 increased lifetime and reduced the number of PCNA+ tumor cells and intensity of neoangiogenesis. Inhibition of matrix metalloproteinase-9 prevented tumor necrosis. The results suggest that matrix metalloproteinase-9 is involved not only in the regulation of extracellular matrix degradation, but also in the processes of cell proliferation and neoangiogenesis in skin melanoma. Therefore, this enzyme can be considered as a potential therapeutic target.

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Authors and Affiliations

  1. Prof. V. V. Ivanov Department of Pathological Physiology with the Course of Clinical Pathophysiology, Prof. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Moscow, Russia

    M. B. Aksenenko & T. G. Ruksha

Authors
  1. M. B. Aksenenko
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  2. T. G. Ruksha
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Correspondence to T. G. Ruksha.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 11, pp. 547-549, November, 2012

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Aksenenko, M.B., Ruksha, T.G. Analysis of the Application of MMP-9 Inhibitor in Skin Melanoma: Experimental Study. Bull Exp Biol Med 154, 594–596 (2013). https://doi.org/10.1007/s10517-013-2007-6

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  • DOI: https://doi.org/10.1007/s10517-013-2007-6

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