General Pathology and Pathophysiology

Bulletin of Experimental Biology and Medicine

, Volume 154, Issue 5, pp 594-596

Analysis of the Application of MMP-9 Inhibitor in Skin Melanoma: Experimental Study

  • M. B. AksenenkoAffiliated withProf. V. V. Ivanov Department of Pathological Physiology with the Course of Clinical Pathophysiology, Prof. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University
  • , T. G. RukshaAffiliated withProf. V. V. Ivanov Department of Pathological Physiology with the Course of Clinical Pathophysiology, Prof. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Experiment on C57Bl/6 mice with modeled skin melanoma showed that selective inhibition of matrix metalloproteinase-9 increased lifetime and reduced the number of PCNA+ tumor cells and intensity of neoangiogenesis. Inhibition of matrix metalloproteinase-9 prevented tumor necrosis. The results suggest that matrix metalloproteinase-9 is involved not only in the regulation of extracellular matrix degradation, but also in the processes of cell proliferation and neoangiogenesis in skin melanoma. Therefore, this enzyme can be considered as a potential therapeutic target.

Key Words

matrix metalloproteinase-9 skin melanoma neoangiogenesis