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Binding of Specific Ligand by D2- and NMDA-Receptors of Striatum Cells in Two Rat Strains Predisposed and Resistant to Audiogenic Seizures

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We studied parameters of specific receptor binding of D2-dopamine receptor ligand [3H]-sulpiride and NMDA-receptor ligand [3H]-MK-801 on the membranes of striatum cells in Krushinsky–Molodkina rats (predisposed to audiogenic seizures) and strain “0” selected for the absence of audiogenic seizures. No interstrain differences were observed in affinity (Kd) of both D2- and NMDA-receptors to ligands. At the same time, significant interstrain differences in receptor density (Bmax) were found for both D2-receptors and NMDA-receptors. The reduced number of dopamine and glutamate receptors in the striatum can be associated with neurological peculiarities of Krushinsky–Molodkina rat strain (audiogenic seizures and postictal catalepsy).

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Authors and Affiliations

  1. V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia

    Ju. Ju. Firstova, D. A. Abaimov & G. I. Kovalev

  2. Department of Higher Nervous Activity, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia

    N. M. Surina, I. I. Poletaeva & I. B. Fedotova

Authors
  1. Ju. Ju. Firstova
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  2. D. A. Abaimov
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  3. N. M. Surina
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  4. I. I. Poletaeva
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  5. I. B. Fedotova
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  6. G. I. Kovalev
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Corresponding author

Correspondence to N. M. Surina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 8, pp. 158–160, August, 2012

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Firstova, J.J., Abaimov, D.A., Surina, N.M. et al. Binding of Specific Ligand by D2- and NMDA-Receptors of Striatum Cells in Two Rat Strains Predisposed and Resistant to Audiogenic Seizures. Bull Exp Biol Med 154, 196–198 (2012). https://doi.org/10.1007/s10517-012-1910-6

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  • DOI: https://doi.org/10.1007/s10517-012-1910-6

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