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Psychoimmunomodulatory Effect of Phenotropil in Animals with Immune Stress

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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of phenotropil (25 mg/kg intraperitoneally, 5 days) on the immune and psychoemotional state of Wistar rats with LPS-induced immune stress. Hyperactivity of the immune system in animals after treatment with Pseudomonas aeruginosa LPS (100 μg/kg intraperitoneally, 3 days) manifested in a significant increase in the delayed-type hypersensitivity index, antibody titer in the reaction of passive hemagglutination, and phagocytic activity of peripheral blood neutrophils. Locomotor, orientation, and exploratory activities were reduced, while anxiety increased in animals with immune stress. Phenotropil exhibited the psychoimmunomodulatory effect under these conditions, which manifested in prevention of anxiety and fear response, increase in horizontal locomotion and exploratory behavior, and improvement of immunoreactivity.

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Authors and Affiliations

  1. Department of Pharmacognosy with the Course of Pharmaceutical Technology and Biotechnology, Astrakhan, Russia

    M. A. Samotrueva, T. K. Serezhnikova & E. B. Khlebtsova

  2. Astrakhan State Medical Academy, Russian Ministry of Health, Astrakhan, Russia

    M. A. Samotrueva, T. K. Serezhnikova & E. B. Khlebtsova

  3. Department of Pharmacology and Biopharmacy, Faculty of Post-training Medical Education, Volgograd State Medical University, Russian Ministry of Health, Volgograd, Russia

    I. N. Tyurenkov

  4. Department for Physiology and Morphology of Humans and Animals, Astrakhan State University, Astrakhan, Russia

    D. L. Teplyi

Authors
  1. M. A. Samotrueva
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  2. I. N. Tyurenkov
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  3. D. L. Teplyi
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  4. T. K. Serezhnikova
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  5. E. B. Khlebtsova
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Correspondence to M. A. Samotrueva.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 151, No. 1, pp. 59-62, January, 2011

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Samotrueva, M.A., Tyurenkov, I.N., Teplyi, D.L. et al. Psychoimmunomodulatory Effect of Phenotropil in Animals with Immune Stress. Bull Exp Biol Med 151, 51–54 (2011). https://doi.org/10.1007/s10517-011-1257-4

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  • DOI: https://doi.org/10.1007/s10517-011-1257-4

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