In male patients with coronary atherosclerosis without acute coronary syndrome, the levels of inflammatory-destructive biomarkers of atherosclerotic plaque instability depended on the severity and dissemination of coronary atherosclerosis. The highest levels of C-reactive protein and matrix metalloproteinase 3 were found in men with atherosclerotic involvement of all three main coronary arteries, primarily their middle and distal segments, and in men with predominance of low-grade stenoses (<50%) of coronary arteries in areas of atherosclerotic plaques.
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References
Yu. I. Ragino, A. M. Cherjyavski, Ya. V. Polonskaja, et al., Byull. Eksp. Biol. Med., 144, No. 11, 500–503 (2007).
Yu. I. Ragino, A. M. Chernjavski, Ya. V. Polonskaja, et al., Kardiologiya, No. 9, 62–67 (2007).
E. J. Armstrong, D. A. Morrow, and M. S. Sabatine, Circulation, 113, No. 6, e72–75 (2006).
E. J. Armstrong, D. A. Morrow, and M. S. Sabatine, Ibid., 113, No. 7, e152–155 (2006).
E. J. Armstrong, D. A. Morrow, and M. S. Sabatine, Ibid., 113, No. 9, e382–385 (2006).
M. Asakura, Y. Ueda, O. Yamaguchi, et al., J. Am. Coll Cardiol., 37, No. 5, 1284–1288 (2001).
J. C. Fruchart, Handbook of Dyslipidemia and Atherosclerosis. France, University of Lille (2003), Pt. 1. pp. 1–65.
J. A. Goldstein, D. Demetriou, C. L. Grines, et al., N. Engl. J. Med., 343, No. 13, 915–922 (2000).
D. G. Katritsis, J. Pantos, and E. Efstathopoulos, Coron. Artery Dis., 18, No. 3, 229–237 (2007).
M. Naghavi, E. Falk, H. S. Hecht, et al., Am. J. Cardiol., 98, No. 2A, 2H–15H (2006).
M. Naghavi, P. Libby, E. Falk, et al., Circulation, 108, No. 14, 1664–1672 (2003).
P. J. Scanlon, D. P. Faxon, A. M. Audet, et al., J. Am. Coll Cardiol., 33, No. 6, 1756–1824 (1999).
P. K. Shah, High-Risk Atherosclerotic Plaques: Mechanisms, Imaging, Models, and Therapy. Ed. L. M. Khachigian, New York (2005), pp. 1–19.
P. K. Shah and B. Sharifi , Biochemistry of Atherosclerosis, Ed. S. K. Cheema, New York (2006), pp. 455–563.
R. Waksman and P. W. Seruys, Handbook of the Vulnerable Plaque. London (2004), pp. 1–48.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 149, No. 5, pp. 520-523, May, 2010
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Ragino, Y.I., Chernjavski, A.M., Polonskaja, Y.V. et al. Blood Levels of Inflammatory and Destructive Biomarkers in Coronary Atherosclerosis of Different Severity. Bull Exp Biol Med 149, 587–590 (2010). https://doi.org/10.1007/s10517-010-0999-8
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DOI: https://doi.org/10.1007/s10517-010-0999-8