Abstract
The mechanism of interaction of hypochlorite and hypobromite formed in myeloperoxidase catalysis with lipids of human blood low-density lipoprotein is described. Both agents react with unsaturated lipids via two mechanisms: molecular (with the formation of mainly chloro-or bromohydrins and lysophospholipids) and free-radical (paralleled by lipid peroxidation). These reactions modify physicochemical properties of low-density lipoproteins and disorder their lipid-transporting function thus initiating early stages of atherosclerosis development.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Supplement 2, pp. 57–60, April, 2007
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Panasenko, O.M., Vakhrusheva, T.V., Vlasova, I.I. et al. Role of myeloperoxidase-mediated modification of human blood lipoproteins in atherosclerosis development. Bull Exp Biol Med 144, 428–431 (2007). https://doi.org/10.1007/s10517-007-0346-x
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DOI: https://doi.org/10.1007/s10517-007-0346-x