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Role of myeloperoxidase-mediated modification of human blood lipoproteins in atherosclerosis development

Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The mechanism of interaction of hypochlorite and hypobromite formed in myeloperoxidase catalysis with lipids of human blood low-density lipoprotein is described. Both agents react with unsaturated lipids via two mechanisms: molecular (with the formation of mainly chloro-or bromohydrins and lysophospholipids) and free-radical (paralleled by lipid peroxidation). These reactions modify physicochemical properties of low-density lipoproteins and disorder their lipid-transporting function thus initiating early stages of atherosclerosis development.

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Correspondence to O. M. Panasenko.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Supplement 2, pp. 57–60, April, 2007

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Panasenko, O.M., Vakhrusheva, T.V., Vlasova, I.I. et al. Role of myeloperoxidase-mediated modification of human blood lipoproteins in atherosclerosis development. Bull Exp Biol Med 144, 428–431 (2007). https://doi.org/10.1007/s10517-007-0346-x

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  • DOI: https://doi.org/10.1007/s10517-007-0346-x

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