Clinical Case Report Series

Archives of Sexual Behavior

, Volume 43, Issue 1, pp 187-189

First online:

Choline Associated Hypersexuality in a 79-Year-Old Man

  • Rocco Salvatore CalabròAffiliated withIRCCS Centro Neurolesi “Bonino-Pulejo” Email author 
  • , Francesco CordiciAffiliated withIRCCS Centro Neurolesi “Bonino-Pulejo”
  • , Carmelo GenoveseAffiliated withAllergology Unit, University of Messina
  • , Placido BramantiAffiliated withIRCCS Centro Neurolesi “Bonino-Pulejo”

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Hypersexuality, also referred to as sexually inappropriate behavior and sexual disinhibition, involves persistent, uninhibited sexual behaviors directed at oneself or at others, sometimes associated with neurodegenerative disorders. Choline is a water-soluble essential nutrient, used as a dietary supplement in different diseases. This report was aimed at considering choline intake as a possible cause of iatrogenic hypersexuality. After an evaluation, a 79-year-old man affected by memory loss was diagnosed with mild cognitive impairment and treated with oral choline. After 6 weeks of regular choline assumption, the patient showed a pathological increase in libido with sexual urges. As choline was withdrawn, the hypersexuality disappeared within 5 days. Since hypersexuality may be an underreported and overlooked adverse effect of drugs and dietary supplements acting on the cholinergic pathway, this should be considered when treating and counselling patients with inappropriate sexual behavior.


Choline Hypersexuality Mild cognitive impairment Neurodegenerative disorders