Archives of Sexual Behavior

, Volume 43, Issue 1, pp 187–189

Choline Associated Hypersexuality in a 79-Year-Old Man


    • IRCCS Centro Neurolesi “Bonino-Pulejo”
  • Francesco Cordici
    • IRCCS Centro Neurolesi “Bonino-Pulejo”
  • Carmelo Genovese
    • Allergology UnitUniversity of Messina
  • Placido Bramanti
    • IRCCS Centro Neurolesi “Bonino-Pulejo”
Clinical Case Report Series

DOI: 10.1007/s10508-013-0137-6

Cite this article as:
Calabrò, R.S., Cordici, F., Genovese, C. et al. Arch Sex Behav (2014) 43: 187. doi:10.1007/s10508-013-0137-6


Hypersexuality, also referred to as sexually inappropriate behavior and sexual disinhibition, involves persistent, uninhibited sexual behaviors directed at oneself or at others, sometimes associated with neurodegenerative disorders. Choline is a water-soluble essential nutrient, used as a dietary supplement in different diseases. This report was aimed at considering choline intake as a possible cause of iatrogenic hypersexuality. After an evaluation, a 79-year-old man affected by memory loss was diagnosed with mild cognitive impairment and treated with oral choline. After 6 weeks of regular choline assumption, the patient showed a pathological increase in libido with sexual urges. As choline was withdrawn, the hypersexuality disappeared within 5 days. Since hypersexuality may be an underreported and overlooked adverse effect of drugs and dietary supplements acting on the cholinergic pathway, this should be considered when treating and counselling patients with inappropriate sexual behavior.


CholineHypersexualityMild cognitive impairmentNeurodegenerative disorders

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© Springer Science+Business Media New York 2013