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Natural products as modulator of autophagy with potential clinical prospects

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Abstract

Natural compounds derived from living organisms are well defined for their remarkable biological and pharmacological properties likely to be translated into clinical use. Therefore, delving into the mechanisms by which natural compounds protect against diverse diseases may be of great therapeutic benefits for medical practice. Autophagy, an intricate lysosome-dependent digestion process, with implications in a wide variety of pathophysiological settings, has attracted extensive attention over the past few decades. Hitherto, accumulating evidence has revealed that a large number of natural products are involved in autophagy modulation, either inducing or inhibiting autophagy, through multiple signaling pathways and transcriptional regulators. In this review, we summarize natural compounds regulating autophagy in multifarious diseases including cancer, neurodegenerative diseases, cardiovascular diseases, metabolic diseases, and immune diseases, hoping to inspire further investigation of the underlying mechanisms of natural compounds and to facilitate their clinical use for multiple human diseases.

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Acknowledgements

We acknowledge support from the National Natural Science Foundation of China (NSFC) (Grant Number 31270399 and Grant Number 81603275), Key Projects of the National Science and Technology Pillar Program (Grant Number 2012BAI30B02), Fund of the Educational Department of Liaoning Province (Grant Number L2011177), Liaoning Baiqianwan Talents Program (Grant Number 2013921043), Liaoning Province Natural Science Foundation (Grant Number 201602689), Scientific Research Foundation for the Returned Overseas Chinese Scholars of Shenyang Pharmaceutical University (Grant Number GGJJ2015103), and 2015 Career Development Program for Young and Middle-aged Teachers of Shenyang Pharmaceutical University (Grant Number ZQN2015015).

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    1. Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China

      Peiqi Wang, Lingjuan Zhu, Dejuan Sun, Feihong Gan, Suyu Gao, Yuanyuan Yin & Lixia Chen

    2. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China

      Peiqi Wang, Feihong Gan & Yuanyuan Yin

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    1. Peiqi Wang
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    2. Lingjuan Zhu
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    Correspondence to Lixia Chen.

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    Peiqi Wang and Lingjuan Zhu have contributed equally to this work.

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    Wang, P., Zhu, L., Sun, D. et al. Natural products as modulator of autophagy with potential clinical prospects. Apoptosis 22, 325–356 (2017). https://doi.org/10.1007/s10495-016-1335-1

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