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Structural insight into CIDE domains: the Janus face of CIDEs

  • The Domains of Apoptosis and Inflammation
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Abstract

Cell-death inducing DFF45-like effect domain (CIDE domain) is a protein interaction module that was initially found in DNA fragmentation factor (DFF) proteins DFF40 and DFF45. Several other CIDE-containing proteins, CIDE-A, CIDE-B, and CIDE-3, have since been identified in humans. Although the main function of these proteins is associated with apoptosis, recent studies have identified roles of CIDE-containing proteins in energy metabolism, especially involvement in control of the size of lipid droplets. Because CIDE-containing proteins perform critical tasks in apoptosis and energy metabolism and have been linked to many human diseases including cancer and obesity, studies of CIDE domains and CIDE-containing proteins are of great biological importance. This review summarizes the structural insight into CIDE and the CIDE–CIDE complex and speculates on a generalized strategy for the CIDE–CIDE interaction based on the available CIDE structures and molecular modelling.

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Acknowledgments

This research was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (HI13C1449).

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Authors and Affiliations

  1. School of Biotechnology and Graduate School of Biochemistry, Yeungnam University, Gyeongsan, South Korea

    Hyun Ho Park

  2. Department of Biotechnology, Yeungnam University, Gyeongsan, South Korea

    Hyun Ho Park

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  1. Hyun Ho Park
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Correspondence to Hyun Ho Park.

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Park, H.H. Structural insight into CIDE domains: the Janus face of CIDEs. Apoptosis 20, 240–249 (2015). https://doi.org/10.1007/s10495-014-1067-z

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