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Structural basis of cell apoptosis and necrosis in TNFR signaling

  • The Domains of Apoptosis and Inflammation
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Abstract

The tumor necrosis factor receptors (TNFRs) play essential roles in innate and adaptive immunity. Depending on conditions, TNFR induces multiple cell fates including cell survival, cell apoptosis, and cell programmed necrosis. Here, we review recent progress in structural studies of the TNFR signaling pathway. The structural basis for the high order signal complexes, including the DISC, ripoptosome, necrosome, and RIP3/MLKL complex, may provide novel insights for understanding the biophysical principles of cell signaling cascades.

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Acknowledgments

We apologize for incomplete citations due to space limitations. The work was supported by the National Natural Science Foundation of China (31470724 to J.L.) and the National Basic Research Program of China (2015CB943300 to J.L.).

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Authors and Affiliations

  1. State Key Laboratory of Genetic Engineering and School of Life Sciences, Fudan University, Shanghai, 200438, China

    Jing Huang, Chaoneng Ji & Jixi Li

  2. Department of Chemistry, Fudan University, Shanghai, 200433, China

    Jing Huang & Shaoning Yu

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  1. Jing Huang
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  2. Shaoning Yu
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  4. Jixi Li
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Correspondence to Jixi Li.

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Huang, J., Yu, S., Ji, C. et al. Structural basis of cell apoptosis and necrosis in TNFR signaling. Apoptosis 20, 210–215 (2015). https://doi.org/10.1007/s10495-014-1061-5

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