Original Paper


, Volume 17, Issue 12, pp 1258-1260

First online:

Retinal endothelial cell apoptosis

  • Jena J. SteinleAffiliated withDepartment of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science CenterDepartment of Anatomy & Neurobiology, University of Tennessee Health Science Center Email author 

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Retinal endothelial cell (REC) apoptosis occurs in response to a number of stressors, including high glucose, oxidative stress, hypoxia. Because these stressors are common factors in a number of ocular diseases, it is critical to understand the cellular mechanisms by which apoptosis occurs in REC. This review discusses the various models of REC used in ophthalmological research. The mechanisms responsible for REC apoptosis are discussed, as well as potential therapeutics currently under development to prevent REC apoptosis. The primary goal of this review is provide the reader with a background knowledge of the current state of research ongoing in REC apoptosis and potential avenues for future testing.


Apoptosis Retina Disease Endothelial cell