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Cyanobacteria: potential candidates for drug discovery

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Antonie van Leeuwenhoek Aims and scope Submit manuscript

Abstract

Cyanobacteria are a rich source of vast array of bioactive molecules including toxins with wide pharmaceutical importance. They show varied bioactivities like antitumor, antiviral, antibacterial, antifungal, antimalarial, antimycotics, antiproliferative, cytotoxicity, immunosuppressive agents and multi-drug resistance reversers. A number of techniques are now developed and standardized for the extraction, isolation, detection and purification of cyanobacterial bioactive molecules. Some of the compounds are showing interesting results and have successfully reached to phase II and phase III of clinical trials. These compounds also serve as lead compounds for the development of synthetic analogues with improved bioactivity. Cyanobacterial bioactive molecules hold a bright and promising future in scientific research and great opportunity for drug discovery. This review mainly focuses on anticancerous, antiviral and antibacterial compounds from cyanobacteria; their clinical status; extraction and detection techniques.

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Acknowledgments

Authors are thankful to Director, CSIR-NBRI for all the facilities and constant encouragement. Rakhi Bajpai Dixit is grateful to Department of Science and Technology (DST, New Delhi), for providing financial assistance in the form of a project (Ref. No. SR/FT/LS-111/2010).

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  1. Algology Section, CSIR-National Botanical Research Institute, Lucknow, 226001, Uttar Pradesh, India

    Rakhi Bajpai Dixit & M. R. Suseela

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  1. Rakhi Bajpai Dixit
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Correspondence to Rakhi Bajpai Dixit.

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Dixit, R.B., Suseela, M.R. Cyanobacteria: potential candidates for drug discovery. Antonie van Leeuwenhoek 103, 947–961 (2013). https://doi.org/10.1007/s10482-013-9898-0

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