Skip to main content
SpringerLink
Log in

A low-noise gain-tunable amplifier for large array biopotential recording systems

  • Mixed Signal Letter
  • Published:
Analog Integrated Circuits and Signal Processing Aims and scope Submit manuscript

Abstract

This paper presents a low-noise gain-tunable biopotential amplifier that is designed based on a folded-cascode structure. Sub-threshold and self-biasing techniques are employed to achieve a low-noise and low-power amplification. With a bias-current tuning block, the gain of the proposed biopotential amplifier can be precisely adjusted. Designed in a standard 0.13 μm CMOS process, the proposed amplifier provides a 5.9 kHz bandwidth and 30.1 dB gain with 732 nW power. The input-referred noise over the entire bandwidth is 4.3 μV rms , equivalent to a noise-efficiency factor of 2.48.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

References

  1. Chaturvedi, V., & Amrutur, B. (2011). An area-efficient noise-adaptive neural amplifier in 130 nm cmos technology. IEEE Journal on Emerging and Selected Topics in Circuits and Systems, 1(4):536–545.

    Article  Google Scholar 

  2. Enz, C. C., Krummenacher, F., & Vittoz, E .A. (1995). An analytical mos transistor model valid in all regions of operation and dedicated to low-voltage and low-current applications. Analog Integrated Circuits and Signal Processing, 8(1):83–114.

    Article  Google Scholar 

  3. Harrison, R. R., & Charles, C. (2003). A low-power low-noise cmos amplifier for neural recording applications. IEEE Journal of Solid-State Circuits 38(6):958–965.

    Article  Google Scholar 

  4. Holleman, J., & Otis, B. (2007). A sub-microwatt low-noise amplifier for neural recording. In 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (pp. 3930–3933). Lyon, France.

  5. Kazerouni, I. A., Dehrizi, H. G., Isfahani, S. M. M., Zhuo, Z., Baghaei-Nejad, M., & Zheng, L. R. (2010). A 77 nw bioamplifier with a tunable bandwidth for neural recording systems. In IEEE Asia Pacific Conference on Circuits and Systems (pp. 36–39).

  6. Kim, J., Chae, M. S., & Liu, W. (2009). A 220 nw neural amplifier for muti-channel neural recording systems. In IEEE International Symposium on Circuits and Systems (pp. 1257–1260).

  7. Liu, L., Zou, X., Goh, W., Ramamoorthy, R., Dawe, G., & Je, M. (2012). 800 nW 43 nV/\(\sqrt{\hbox{Hz}}\) neural recording amplifier with enhanced noise efficiency factor. Electronics Letters, 48(9):479–480.

    Article  Google Scholar 

  8. Majidzadeh, V., Schmid, A., & Leblebici, Y. (2011). Energy efficient low-noise neural recording amplifier with enhanced noise efficiency factor. IEEE Transactions on Biomedical Circuits and Systems, 5(3):262–271.

    Article  Google Scholar 

  9. PhysioNet, PhysioBank. (2011). Shhs polysomnography database @ONLINE. http://physionet.org/physiobank/database/shhpsgdb/

  10. Seese, T. M., Harasaki, H., Saidel, G. M., & Davies, C. R. (1998). Characterization of tissue morphology, angiogenesis, and temperature in the adaptive response of muscle tissue to chronic heating. Laboratory Investigation, 8(12):1553–1562.

    Google Scholar 

  11. Webster, J. G. (2009). Medical instrumentation application and design (4th edn.). New York: Wiley.

    Google Scholar 

  12. Zhang, F., Holleman, J., & Otis, B. P. (2012). Design of ultra-low power biopotential amplifiers for biosignal acquisition applications. IEEE Transactions on Biomedical Circuits and Systems, 6(4):344-355.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Electrical and Computer Engineering, The University of Alabama at Birmingham, 35294-4551, Birmingham, AL, USA

    Yang-Guo Li, Mohammad Rafiqul Haider & Yehia Massoud

Authors
  1. Yang-Guo Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mohammad Rafiqul Haider
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yehia Massoud
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mohammad Rafiqul Haider.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Li, YG., Haider, M.R. & Massoud, Y. A low-noise gain-tunable amplifier for large array biopotential recording systems. Analog Integr Circ Sig Process 74, 485–489 (2013). https://doi.org/10.1007/s10470-012-0013-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10470-012-0013-7

Keywords

Search

Navigation