Abstract
Sub-Saharan Africa bears 69 % of the global burden of HIV, and strong evidence indicates an association between alcohol consumption, HIV risk behavior, and HIV incidence. However, characteristics of efficacious HIV-alcohol risk reduction interventions are not well known. The purpose of this systematic review is to summarize the characteristics and synthesize the findings of HIV-alcohol risk reduction interventions implemented in the region and reported in peer-reviewed journals. Of 644 citations screened, 19 met the inclusion criteria for this review. A discussion of methodological challenges, research gaps, and recommendations for future interventions is included. Relatively few interventions were found, and evidence is mixed about the efficacy of HIV-alcohol risk reduction interventions. There is a need to further integrate HIV-alcohol risk reduction components into HIV prevention programming and to document results from such integration. Additionally, research on larger scale, multi-level interventions is needed to identify effective HIV-alcohol risk reduction strategies.
Resumen
El África subsahariana tiene el 69 % de la carga mundial de VIH, y una fuerte evidencia indica que el consumo de alcohol, la conducta de riesgo del VIH, y la incidencia del VIH están asociados. Sin embargo, las características de intervenciones eficaces para la reducción de riesgo de VIH-alcohol no son bien conocidas. El propósito de esta revisión sistemática es resumir las características de las intervenciones de reducción de riesgo de VIH-alcohol que se han implementado en la región y reportado en revistas científicas y sintetizar los hallazgos. De 644 estudios, 19 cumplieron los criterios para ser incluidos en este artículo. En este estudio analizamos los desafíos metodológicos, lagunas en la investigación y ofrecemos recomendaciones para futuras intervenciones. Encontramos que relativamente pocas intervenciones han sido evaluadas, y la evidencia sobre la eficacia de las intervenciones de reducción de riesgo de VIH-alcohol no es clara ya que solo algunos estudios reportan efectos los cuales generalmente se disipan en el largo plazo. Existe la necesidad de una mayor integración de componentes de reducción de riesgo de VIH-alcohol en los programas de prevención del VIH y de documentar los resultados de dicha integración. Además, se necesita investigación sobre intervenciones de mayor escala y en varios niveles para determinar estrategias eficaces en la reducción de toma de riesgos relacionados con el consumo de alcohol y el VIH.
Similar content being viewed by others
References
Jernigan DH, Babor TF. The concentration of the global alcohol industry and its penetration in the African region. Addiction. 2015;10(4):551–60.
World Health Organization. Global status report on alcohol and health. Geneva 2014.
Ferreira-Borges C, Esser MB, Parry CD, Dias S, Babor TF. Alcohol control policies in 46 African countries: opportunities to improve. Alcohol Alcohol. 2015;50(4):470–6.
Bryant KJ. Expanding research on the role of alcohol consumption and related risks in the prevention and treatment of HIV/AIDS. Subst Use Misuse. 2006;41(10–12):1465–507.
Baliunas D, Rehm J, Irving H, Shuper P. Alcohol consumption and risk of incident human immunodeficiency virus infection: a meta-analysis. Int J Public Health. 2010;55(3):159–66.
Cook RL, Clark DB. Is there an association between alcohol consumption and sexually transmitted diseases? A systematic review. Sex Transm Dis. 2005;32(3):156–64.
Kalichman SC, Simbayi LC, Vermaak R, Cain D, Jooste S, Peltzer K. HIV/AIDS risk reduction counseling for alcohol using sexually transmitted infections clinic patients in Cape Town, South Africa. J Acquir Immune Defic Syndr. 2007;44(5):594–600.
Shuper PA, Neuman M, Kanteres F, Baliunas D, Joharchi N, Rehm J. Causal considerations on alcohol and HIV/AIDS–a systematic review. Alcohol Alcohol. 2010;45(2):159–66.
Zablotska IB, Gray RH, Serwadda D, et al. Alcohol use before sex and HIV acquisition: a longitudinal study in Rakai, Uganda. AIDS. 2006;20(8):1191–6.
UNAIDS. UNAIDS Regional Fact Sheet 2012: Sub-Saharan Africa. 2012. Available at: http://www.unaids.org/en/media/unaids/contentassets/documents/epidemiology/2012/gr2012/2012_FS_regional_ssa_en.pdf. Accessed 6 June 2013
Kapiga SH, Sam NE, Shao JF, et al. HIV-1 epidemic among female bar and hotel workers in northern Tanzania: risk factors and opportunities for prevention. J Acquir Immune Defic Syndr. 2002;29(4):409–17.
Kalichman S, Simbayi LC, Kaufman M, Cain D, Jooste S. Alcohol use and sexual risks for HIV/AIDS in sub-Saharan Africa: systematic review of empirical findings. Prev Sci. 2007;8(2):141–51.
Avalos LA, Mertens JR, Ward CL, Flisher AJ, Bresick GF, Weisner CM. Stress, substance use and sexual risk behaviors among primary care patients in Cape Town, South Africa. AIDS Behav. 2010;14(2):359–70.
Lane T, Shade SB, McIntyre J, Morin SF. Alcohol and sexual risk behavior among men who have sex with men in South african township communities. AIDS Behav. 2008;12(4 Suppl):S78–85.
Mpofu E, Flisher AJ, Bility K, Onya H, Lombard C. Sexual partners in a rural South African setting. AIDS Behav. 2006;10(4):399–404.
Myer L, Mathews C, Little F. Condom use and sexual behaviors among individuals procuring free male condoms in South Africa: a prospective study. Sex Transm Dis. 2002;29(4):239–41.
Kalichman S, Simbayi L, Jooste S, Cain D, Cherry C. Sensation seeking, alcohol use, and sexual behaviors among sexually transmitted infection clinic patients in Cape Town, South Africa. Psychol Addict Behav. 2006;20(3):298–304.
Fisher JC, Bang H, Kapiga SH. The association between HIV infection and alcohol use: a systematic review and meta-analysis of African studies. Sex Transm Dis. 2007;34(11):856–63.
Hahn JA, Woolf-King SE, Muyindike W. Adding fuel to the fire: alcohol’s effect on the HIV epidemic in Sub-Saharan Africa. Curr HIV/AIDS Rep. 2011;8(3):172–80.
Morojele NK, Ranchod C. Review of interventions to reduce alcohol use-related sexual risk behaviour in Africa. Afr J Drug Alcohol Stud. 2011;10(2):95–106.
Lan CW, Scott-Sheldon LA, Carey KB, Johnson BT, Carey MP. Alcohol and sexual risk reduction interventions among people living in Russia: a systematic review and meta-analysis. AIDS Behav. 2014;18(10):1835–46.
Jackson C, Geddes R, Haw S, Frank J. Interventions to prevent substance use and risky sexual behaviour in young people: a systematic review. Addiction. 2012;107(4):733–47.
Fritz K, Morojele N, Kalichman S. Alcohol: the forgotten drug in HIV/AIDS. Lancet. 2010;376(9739):398–400.
Chersich MF, Rees HV. Causal links between binge drinking patterns, unsafe sex and HIV in South Africa: its time to intervene. Int J STD AIDS. 2010;21(1):2–7.
Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151(4):264–9 W64.
The Guide to Community Preventive Services. Systematic Review Methods. 2014. Available at: http://thecommunityguide.org/about/methods.html. Accessed 21 Sept 2014
Essien EJ, Mgbere O, Monjok E, Ekong E, Holstad MM, Kalichman SC. Effectiveness of a video-based motivational skills-building HIV risk-reduction intervention for female military personnel. Soc Sci Med. 2011;72(1):63–71.
Fritz K, McFarland W, Wyrod R, et al. Evaluation of a peer network-based sexual risk reduction intervention for men in beer halls in Zimbabwe: results from a randomized controlled trial. AIDS Behav. 2011;15(8):1732–44.
Kalichman S, Simbayi L, Vermaak R, et al. Randomized trial of a community-based alcohol-related HIV risk-reduction intervention for men and women in Cape Town South Africa. Ann Behav Med. 2008;36(3):270–9.
Kalichman SC, Cain D, Eaton L, Jooste S, Simbayi LC. Randomized clinical trial of brief risk reduction counseling for sexually transmitted infection clinic patients in Cape Town, South Africa. Am J Public Health. 2011;101(9):e9–17.
Peltzer K, Tabane C, Matseke G, Simbayi L. Lay counsellor-based risk reduction intervention with HIV positive diagnosed patients at public HIV counselling and testing sites in Mpumalanga, South Africa. Eval Program Plann. 2010;33(4):379–85.
Wechsberg WM, Zule WA, Luseno WK, et al. Effectiveness of an adapted evidence-based woman-focused intervention for sex workers and non-sex workers: the Women’s Health CoOp in South Africa. J Drug Issues. 2011;41(2):233–52.
Cupp PK, Zimmerman RS, Bhana A, et al. Combining and adapting American school-based alcohol and HIV prevention programmes in South Africa: the HAPS project. Vulnerable Children Youth Stud. 2008;3(2):134–42.
Zule W, Myers B, Carney T, Novak SP, McCormick K, Wechsberg WM. Alcohol and drug use outcomes among vulnerable women living with HIV: results from the Western Cape Women’s Health CoOp. AIDS Care. 2014;26(12):1494–9.
Wechsberg WM, Luseno WK, Lam WK, Parry CD, Morojele NK. Substance use, sexual risk, and violence: HIV prevention intervention with sex workers in Pretoria. AIDS Behav. 2006;10(2):131–7.
Wechsberg WM, Jewkes R, Novak SP, et al. A brief intervention for drug use, sexual risk behaviours and violence prevention with vulnerable women in South Africa: a randomised trial of the Women’s Health CoOp. BMJ Open. 2013;3(5):e002622.
Wechsberg W, Luseno W, Karg R, et al. Alcohol, cannabis, and methamphetamine use and other risk behaviours among Black and Coloured South African women: a small randomized trial in the Western Cape. Int J Drug Policy. 2008;19(2):130–9.
Karnell AP, Cupp PK, Zimmerman RS, Feist-Price S, Bennie T. Efficacy of an American alcohol and HIV prevention curriculum adapted for use in South Africa: results of a pilot study in five township schools. AIDS Educ Prev. 2006;18(4):295–310.
Jones D, Weiss SM, Arheart K, Cook R, Chitalu N. Implementation of HIV prevention interventions in resource limited settings: the partner project. J Community Health. 2014;39(1):151–8.
Hahn JA, Fatch R, Wanyenze RK, et al. Decreases in self-reported alcohol consumption following HIV counseling and testing at Mulago Hospital, Kampala, Uganda. BMC Infect Dis. 2014;14:403.
Jewkes R, Nduna M, Levin J, et al. Impact of Stepping Stones on incidence of HIV and HSV-2 and sexual behaviour in rural South Africa: cluster randomised controlled trial. BMJ. 2008;337:a506.
Kalichman S, Simbayi L, Cloete A, et al. Integrated gender-based violence and HIV risk reduction intervention for South African men: results of a quasi-experimental field trial. Prev Sci. 2009;10(3):260–9.
Smith EA, Palen L, Caldwell LL, et al. Substance use and sexual risk prevention in Cape Town, South Africa: an evaluation of the HealthWise program. Prev Sci. 2008;9(4):311–21.
Bing EG, Cheng KG, Ortiz DJ, et al. Evaluation of a prevention intervention to reduce HIV Risk among Angolan soldiers. AIDS Behav. 2008;12(3):384–95.
Jones DJ, Chitalu N, Ndubani P, et al. Sexual risk reduction among Zambian couples. SAHARA J. 2009;6(2):69–75.
AIDSTAR-One. South Africa HealthWise Program. Available at: http://www.aidstar-one.com/promising_practices_database/g3ps/south_africa_healthwise_program. Accessed 5 Oct 2014
TimeWise Description. Available at: http://www.personal.psu.edu/llc7/TimeWise.htm. Accessed 5 Oct 2014
The Voluntary HIV-1 Counseling and Testing Efficacy Study Group. Efficacy of voluntary HIV-1 counselling and testing in individuals and couples in Kenya, Tanzania, and Trinidad: a randomised trial. Lancet. 2000;356(9224):103–12.
Skevington SM, Sovetkina EC, Gillison FB. A systematic review to quantitatively evaluate ‘Stepping Stones’: a participatory community-based HIV/AIDS prevention intervention. AIDS Behav. 2013;17(3):1025–39.
Stepping Stones - What is it? 2013. Available at: http://www.steppingstonesfeedback.org/index.php/About/What_is_it/gb. Accessed 6 Oct 2014
Bandura A. Self-efficacy: the exercise of control. New York: Freeman; 1997.
Fisher JD, Fisher WA. Changing AIDS-risk behavior. Psychol Bull. 1992;111(3):455–74.
Saunders JB, Aasland OG, Babor T, Grant M. Development of the alcohol use disorders identification test (AUDIT): WHO collaborative project on early detection of persons with harmful alcohol consumption-II. Addiction. 1993;88(6):791–804.
Johnson BT, Scott-Sheldon LA, Carey MP. Meta-synthesis of health behavior change meta-analyses. Am J Public Health. 2010;100(11):2193–8.
Johnson BT, Redding CA, DiClemente RJ, et al. A network-individual-resource model for HIV prevention. AIDS Behav. 2010;14(Suppl 2):204–21.
Kaufman MR, Cornish F, Zimmerman RS, Johnson BT. Health behavior change models for HIV prevention and AIDS care: practical recommendations for a multi-level approach. J Acquir Immune Defic Syndr. 2014;66(Suppl 3):S250–8.
Baral S, Beyrer C, Muessig K, et al. Burden of HIV among female sex workers in low-income and middle-income countries: a systematic review and meta-analysis. Lancet Infect Dis. 2012;12(7):538–49.
Li Q, Li X, Stanton B. Alcohol use among female sex workers and male clients: an integrative review of global literature. Alcohol Alcohol. 2010;45(2):188–99.
Centers for Disease Control and Prevention. Vital signs: Binge drinking prevalence, frequency, and intensity among adults—United States, 2010. MMWR Morb Mortal Wkly Rep. 2012;61(1):14–9.
Schneider M, Chersich M, Neuman M, Parry C. Alcohol consumption and HIV/AIDS: the neglected interface. Addiction. 2012;107(8):1369–71.
Shuper PA, Joharchi N, Irving H, Rehm J. Alcohol as a correlate of unprotected sexual behavior among people living with HIV/AIDS: review and meta-analysis. AIDS Behav. 2009;13(6):1021–36.
Parry C, Rehm J, Poznyak V, Room R. Alcohol and infectious diseases: an overlooked causal linkage? Addiction. 2009;104(3):331–2.
Center for Communication Programs. President Kikwete of Tanzania: a CCP Admirer. Baltimore. 2012. Available at: https://www.jhuccp.org/news/president-kikwete-tanzania-ccp-admirer. Accessed 5 Oct 2014
Knudsen HK, Staton-Tindall M, Oser CB, Havens JR, Leukefeld CG. Reducing risky relationships: a multisite randomized trial of a prison-based intervention for reducing HIV sexual risk behaviors among women with a history of drug use. AIDS Care. 2014;26(9):1071–9.
Pettifor A, Corneli A, Kamanga G, et al. HPTN 062: a pilot randomized controlled trial exploring the effect of a motivational-interviewing intervention on sexual behavior among individuals with acute HIV infection in Lilongwe, Malawi. PLoS ONE. 2015;10(5):e0124452.
Ybarra ML, Korchmaros JD, Prescott TL, Birungi R. A randomized controlled trial to increase HIV preventive information, motivation, and behavioral skills in Ugandan adolescents. Ann Behav Med. 2015;49(3):473–85.
Babor TF, Caetano R, Casswell S, et al. Alcohol: no ordinary commodity. 2nd ed. New York: Oxford University Press; 2010.
World Health Organization. Global strategy to reduce the harmful use of alcohol. Geneva: 2010
Staras SA, Livingston MD, Christou AM, Jernigan DH, Wagenaar AC. Heterogeneous population effects of an alcohol excise tax increase on sexually transmitted infections morbidity. Addiction. 2014;109(6):904–12.
Chesson H, Harrison P, Kassler WJ. Sex under the influence: the effect of alcohol policy on sexually transmitted disease rates in the United States. J Law Econ. 2000;43(1):215–38.
Pitso JM, Obot IS. Botswana alcohol policy and the presidential levy controversy. Addiction. 2011;106(5):898–905.
Sebego M, Naumann RB, Rudd RA, Voetsch K, Dellinger AM, Ndlovu C. The impact of alcohol and road traffic policies on crash rates in Botswana, 2004–2011: a time-series analysis. Accid Anal Prev. 2014;70:33–9.
Acknowledgments
We would like to thank Drs. Deanna Kerrigan and Susan Sherman for reviewing earlier drafts of this paper and providing invaluable guidance and Librarian Ms. Victoria Riese for assistance with the search strategy. M.A. Carrasco was supported by the National Institute of Allergy and Infectious Disease (T32 AI050056-12).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Carrasco, M.A., Esser, M.B., Sparks, A. et al. HIV-Alcohol Risk Reduction Interventions in Sub-Saharan Africa: A Systematic Review of the Literature and Recommendations for a Way Forward. AIDS Behav 20, 484–503 (2016). https://doi.org/10.1007/s10461-015-1233-5
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10461-015-1233-5