AIDS and Behavior

, Volume 20, Issue 5, pp 1049–1059

A Randomized Controlled Trial of Personalized Text Message Reminders to Promote Medication Adherence Among HIV-Positive Adolescents and Young Adults

  • Robert Garofalo
  • Lisa M. Kuhns
  • Anna Hotton
  • Amy Johnson
  • Abigail Muldoon
  • Dion Rice
Original Paper

DOI: 10.1007/s10461-015-1192-x

Cite this article as:
Garofalo, R., Kuhns, L.M., Hotton, A. et al. AIDS Behav (2016) 20: 1049. doi:10.1007/s10461-015-1192-x

Abstract

HIV-positive adolescents and young adults often experience suboptimal medication adherence, yet few interventions to improve adherence in this group have shown evidence of efficacy. We conducted a randomized trial of a two-way, personalized daily text messaging intervention to improve adherence to antiretroviral therapy (ART) among N = 105 poorly adherent HIV-positive adolescents and young adults, ages 16–29. Adherence to ART was assessed via self-reported visual analogue scale (VAS; 0–100 %) at 3 and 6-months for mean adherence level and proportion ≥90 % adherent. The average effect estimate over the 6-month intervention period was significant for ≥90 % adherence (OR = 2.12, 95 % CI 1.01–4.45, p < .05) and maintained at 12-months (6 months post-intervention). Satisfaction scores for the intervention were very high. These results suggest both feasibility and initial efficacy of this approach. Given study limitations, additional testing of this intervention as part of a larger clinical trial with objective and/or clinical outcome measures of adherence is warranted.

Keywords

HIV infection Medication adherence Youth Text messaging 

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Robert Garofalo
    • 1
    • 2
  • Lisa M. Kuhns
    • 1
    • 2
  • Anna Hotton
    • 3
  • Amy Johnson
    • 1
    • 4
  • Abigail Muldoon
    • 1
  • Dion Rice
    • 1
  1. 1.Division of Adolescent MedicineAnn & Robert H. Lurie Children’s HospitalChicagoUSA
  2. 2.Department of PediatricsNorthwestern University, Feinberg School of MedicineChicagoUSA
  3. 3.Division of Infectious DiseasesJohn H. Stroger Hospital of Cook CountyChicagoUSA
  4. 4.AIDS Foundation of ChicagoChicagoUSA