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Physical Activity is Associated with Better Neurocognitive and Everyday Functioning Among Older Adults with HIV Disease

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Abstract

We examined the association between physical activity (PA), neurocognitive impairment (NCI), and instrumental activities of daily living (IADLs) among older HIV+ persons. One hundred older HIV+ adults completed the International Physical Activity Questionnaire, a neurocognitive battery, and IADL scale. Higher levels of moderate PA were associated with lower odds of NCI (p = 0.01), even when covariates were modeled. The association between moderate PA and NCI was driven by executive function (p = 0.04). Higher levels of moderate PA were also associated with lower odds of IADL Dependence (p = 0.03), although this fell to a trend (p = 0.08) when including covariates. Follow-up analysis showed those with both NCI and IADL Dependence had lower moderate PA than those with neither (p = 0.03). While these cross-sectional findings suggest PA is associated with better neurocognitive and everyday functioning in older HIV+ adults, longitudinal studies utilizing objective PA methods are needed to evaluate directionality and mechanisms.

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Acknowledgments

This work was primarily supported by ID10-SD-057 from California HIV/AIDS Research Program (CHRP) (Determinants of Successful Aging Among Older HIV+ Persons, D.J. Moore, PI) and the University of California San Diego (UCSD) Stein Institute for Research on Aging Faculty Pilot Research Grant, with additional support from the following National Institutes of Health (NIH) Grants: P30MH062512 [The HIV Neurobehavioral Research Center (HNRC)]; N01 MH22005, HHSN271201000036C, and HHSN271201000030C [The CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER)]; P50DA026306 [The Translational Methamphetamine AIDS Research Center (TMARC)]; U01MH083506 and R24MH59745 [California NeuroAIDS Tissue Network (CNTN)]. Dr. Fazeli is supported by R25MH081482 from NIMH (Interdisciplinary Research Fellowship in NeuroAIDS, M. Cherner, PI), ID10-SD-057 from California HIV/AIDS Research Program (CHRP) (Determinants of Successful Aging Among Older HIV+ Persons, D.J. Moore, PI), R01MH099987 from NIMH (Multi-Dimensional Successful Aging Among HIV-Infected Adults, D. Jeste/D.J. Moore, co-PIs), L30-AG045921 from NIA (Mechanisms of Successful Cognitive and Functional Aging with HIV, P. Fazeli, PI), and 1K99 AG048762-01 from NIA (A Novel Neurorehabilitation Approach for Cognitive Aging with HIV, P. Fazeli, PI).

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Authors and Affiliations

  1. Department of Psychiatry, University of California San Diego, San Diego, CA, USA

    Pariya L. Fazeli, Maria J. Marquine, Catherine Dufour, Brook L. Henry, Ben Gouaux, Raeanne C. Moore, Igor Grant, Dilip V. Jeste & David J. Moore

  2. Department of Medicine, University of California San Diego, San Diego, CA, USA

    Scott L. Letendre

  3. Stein Institute for Research on Aging, University of California San Diego, San Diego, CA, USA

    Maria J. Marquine, Raeanne C. Moore & Dilip V. Jeste

  4. SDSU/UCSD Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA

    Jessica Montoya

  5. Department of Psychology, University of Houston, Houston, TX, USA

    Steven Paul Woods

  6. HIV Neurobehavioral Research Program, University of California San Diego, 220 Dickinson Street, Suite B (8231), San Diego, CA, 92103, USA

    David J. Moore

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  1. Pariya L. Fazeli
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Fazeli, P.L., Marquine, M.J., Dufour, C. et al. Physical Activity is Associated with Better Neurocognitive and Everyday Functioning Among Older Adults with HIV Disease. AIDS Behav 19, 1470–1477 (2015). https://doi.org/10.1007/s10461-015-1024-z

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