Original Paper

AIDS and Behavior

, Volume 17, Issue 2, pp 790-800

Effect of Computer-Assisted Interviewing on Self-Reported Sexual Behavior Data in a Microbicide Clinical Trial

  • Pamina M. GorbachAffiliated withDepartment of Epidemiology, University of California, Los Angeles Email author 
  • , Barbara S. MenschAffiliated withPopulation Council
  • , Marla HusnikAffiliated withFred Hutchinson Cancer Research Center
  • , Astou ColyAffiliated withDepartment of Epidemiology, University of California, Los Angeles
  • , Benoit MâsseAffiliated withFred Hutchinson Cancer Research CenterCHU Sainte-Justine Research Center, Université de Montréal
  • , Bonus MakananiAffiliated withCollege of Medicine-Johns Hopkins University Research Project, Queen Elizabeth Central Hospital
  • , Chiwawa NkhomaAffiliated withCollege of Medicine-Johns Hopkins University Research Project, Queen Elizabeth Central Hospital
  • , Lameck ChinulaAffiliated withUNC Project, Tidziwe Centre, Kamuzu Central Hospital
  • , Tchangani TemboAffiliated withUNC Project, Tidziwe Centre, Kamuzu Central Hospital
    • , Stan MierzwaAffiliated withPopulation Council
    • , Kimberly ReynoldsAffiliated withUNC Project, Tidziwe Centre, Kamuzu Central Hospital
    • , Stacey HurstAffiliated withCollege of Medicine-Johns Hopkins University Research Project, Queen Elizabeth Central Hospital
    • , Anne ColettiAffiliated withFamily Health International
    • , Andrew ForsythAffiliated withNational Institute of Mental Health, NIH

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Abstract

In a microbicide safety and effectiveness trial (HPTN 035) in Malawi, 585 women completed the same questionnaire through a face-to-face interview (FTFI) and an audio computer-assisted self-interview (ACASI). Concordance between FTFI and ACASI responses ranged from 72.0 % for frequency of sex in the past week to 95.2 % for anal intercourse (AI) in the past 3 months. Reported gel and condom use at last sex act were marginally lower with ACASI than FTFI (73.5 % vs. 77.2 %, p = 0.11 and 60.9 % vs. 65.5 %, p = 0.05, respectively). More women reported AI with ACASI than FTFI (5.0 % vs. 0.2 %, p < 0.001). Analyses of consistency of responses within ACASI revealed that 15.0 % of participants in the condom-only arm and 28.7 % in the gel arm provided at least one discrepant answer regarding total sex acts and sex acts where condom and gel were used (19.2 % reported one inconsistent answer, 8.1 % reported two inconsistent answers, and 1.4 % reported three inconsistent answers). While ACASI may provide more accurate assessments of sensitive behaviors in HIV prevention trials, it also results in a high level of internally inconsistent responses.

Keywords

ACASI interviewing Microbicides Sexual behavior reporting