Date: 28 Sep 2010
Once Daily Dosing Improves Adherence to Antiretroviral Therapy
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We studied the association of once-daily dosing with self-reported adherence among participants of the Ontario Cohort Study who were currently taking ART and who had completed a 90-min interviewer-administered questionnaire. Suboptimal adherence was defined as missing ≥1 dose of ART in the 4 days prior to the interview. Participants (n = 779) were 85% male, 69% men having sex with men, 67% white, median age 48 years (IQR 42–54), median years of ART 9 (IQR 5–13) and median CD4 count 463 cells/mm3 (IQR 320–638). Fifteen percent of participants reported suboptimal adherence in the 4 days prior to the interview. In a multivariable logistic regression model, participants on once daily regimens were half as likely to miss a dose during the 4 days prior to the interview. Other independent correlates of suboptimal adherence were younger age, lower positive social interaction and increased frequency of consuming > 6 alcoholic drinks on one occasion.
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- Once Daily Dosing Improves Adherence to Antiretroviral Therapy
AIDS and Behavior
Volume 15, Issue 7 , pp 1397-1409
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
- Additional Links
- Antiretroviral therapy
- Once-daily dosing
- Industry Sectors
- Author Affiliations
- 1. Division of Infectious Disease, University Health Network, Room 5-244, 60 Murray Street, Box 18, Toronto, ON, M5T 3L9, Canada
- 2. Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
- 3. Departments of Medicine and Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada
- 4. The University of Ottawa, The Ottawa Hospital Division of Infectious Diseases, Ottawa, ON, Canada
- 5. Centre for Research on Inner City Health, The Keenan Research Centre in the Li Ka Shing Knowledge Institute and Division of General Internal Medicine, St. Michael’s Hospital, Toronto, ON, Canada
- 6. Ontario HIV Treatment Network, Toronto, ON, Canada
- 7. Department of Psychiatry, University of Toronto, Toronto, ON, Canada
- 8. Division of Infectious Diseases, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
- 9. Health Outcomes and Pharmaco Economics (HOPE) Research Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
- 10. Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
- 11. Maple Leaf Medical Clinic, Toronto, ON, Canada
- 12. Women’s College Research Institute, Women’s College Hospital, Toronto, ON, Canada