AIDS and Behavior

, Volume 15, Issue 2, pp 407–421

Assessing the Reporting of Adherence and Sexual Activity in a Simulated Microbicide Trial in South Africa: An Interview Mode Experiment Using a Placebo Gel

  • Barbara S. Mensch
  • Paul C. Hewett
  • Sharon Abbott
  • Johanna Rankin
  • Sarah Littlefield
  • Khatija Ahmed
  • Nazira Cassim
  • Smruti Patel
  • Gita Ramjee
  • Thesla Palanee
  • Stan Mierzwa
  • Stephanie Skoler-Karpoff
Original Paper

DOI: 10.1007/s10461-010-9791-z

Cite this article as:
Mensch, B.S., Hewett, P.C., Abbott, S. et al. AIDS Behav (2011) 15: 407. doi:10.1007/s10461-010-9791-z

Abstract

Misreporting of adherence undermines detection of an association between product use and HIV infection in microbicide trials. This study investigates whether, in a placebo trial, audio computer-assisted self-interviewing (ACASI) produces more accurate reporting of adherence and sexual behavior than a face-to-face interview (FTFI). At three South African clinics, 849 women were enrolled and instructed to use applicators filled with placebo gel; participants were randomly assigned to FTFI or ACASI. Behavioral reports were validated through two biomarkers that detect product usage and unprotected sex. For most behaviors, ACASI generated significantly higher reporting, although differences by interview mode appeared to diminish over time. ACASI participants were more likely to report having had sex without gel, but reported and tested applicators did not indicate greater honesty about gel insertion with ACASI. While comparisons of reported unprotected sex with the validated biomarker revealed more agreement with ACASI than with FTFI, differences were small.

Keywords

ACASIAdherenceBiomarkersMicrobicidesSexual activity

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Barbara S. Mensch
    • 1
  • Paul C. Hewett
    • 2
  • Sharon Abbott
    • 1
  • Johanna Rankin
    • 1
  • Sarah Littlefield
    • 1
  • Khatija Ahmed
    • 3
  • Nazira Cassim
    • 3
  • Smruti Patel
    • 4
  • Gita Ramjee
    • 5
  • Thesla Palanee
    • 6
  • Stan Mierzwa
    • 1
  • Stephanie Skoler-Karpoff
    • 7
  1. 1.Population CouncilNew YorkUSA
  2. 2.Population CouncilLusakaZambia
  3. 3.Setshaba Research CentreUniversity of Limpopo/Medunsa CampusSoshanguveSouth Africa
  4. 4.Empilisweni Centre for Wellness StudiesUniversity of Cape TownGugulethuSouth Africa
  5. 5.Isipingo ClinicMedical Research CouncilIsipingoSouth Africa
  6. 6.Reproductive Health and HIV Research Unit, Tshireletso Wellness CentreChris Hani Baragwanath HospitalJohannesburgSouth Africa
  7. 7.Memorial Sloan Kettering Cancer CenterNew YorkUSA