Acta Biotheoretica

, Volume 63, Issue 1, pp 23–31

An Embedded Automaton to Monitor the Glycolysis Process in Pancreatic β-Cells

  • R. Selvakumar
  • M. Rashith Muhammad
  • G. Poornima Devi
Regular Article

DOI: 10.1007/s10441-014-9241-9

Cite this article as:
Selvakumar, R., Muhammad, M.R. & Devi, G.P. Acta Biotheor (2015) 63: 23. doi:10.1007/s10441-014-9241-9

Abstract

An embedded automaton is introduced to monitor the whole glycolysis process in pancreatic β-cell and it is a hybridization of both non-deterministic finite automaton and push-down automaton. The set of irreversible and reversible reactions in the glycolysis process are related to non-deterministic finite automaton and push-down automaton respectively. The embedded automaton is used to observe the glucose metabolism with the states of acceptance and rejection. The acceptance state of the embedded automaton depicts the normal level of glycolysis and insulin secretion. The rejection state of this machine shows inhibition of glycolysis which obstructs the secretion of insulin. The subsequent low level of insulin leads to the high blood glucose level also known as hyperglycemia. In this study, the designed machine can be used to regulate the process of glycolysis through a group of regulatory glycolytic enzymes for the treatment of Diabetes mellitus at molecular level.

Keywords

Embedded automata Enzymes Glycolysis Pancreatic β-cell 

Abbreviations

EA

Embedded automata

GK

Glucokinase

GKAs

Glucokinase activators

GLUT

Glucose transporter

NFA

Non-deterministic finite automata

PDA

Push-down automata

NAD

Nicotinamide adenine dinucleotide

Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • R. Selvakumar
    • 1
  • M. Rashith Muhammad
    • 1
  • G. Poornima Devi
    • 2
  1. 1.School of Advanced SciencesVIT UniversityVelloreIndia
  2. 2.Institute of Pharmacy and Molecular BiotechnologyHeidelberg UniversityHeidelbergGermany

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