Regular Article

Acta Biotheoretica

, Volume 61, Issue 1, pp 91-107

First online:

Mathematical Modeling of Respiratory System Mechanics in the Newborn Lamb

  • Virginie Le RolleAffiliated withINSERM, U1099Université de Rennes 1, LTSI Email author 
  • , Nathalie SamsonAffiliated withDepartment of Pediatrics, University of Sherbrooke
  • , Jean-Paul PraudAffiliated withDepartment of Pediatrics, University of Sherbrooke
  • , Alfredo I. HernándezAffiliated withINSERM, U1099Université de Rennes 1, LTSI

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In this paper, a mathematical model of the respiratory mechanics is used to reproduce experimental signal waveforms acquired from three newborn lambs. As the main challenge is to determine specific lamb parameters, a sensitivity analysis has been realized to find the most influent parameters, which are identified using an evolutionary algorithm. Results show a close match between experimental and simulated pressure and flow waveforms obtained during spontaneous ventilation and pleural pressure variations acquired during the application of positive pressure, since root mean square errors equal to 0.0119, 0.0052 and 0.0094. The identified parameters were discussed in light of previous knowledge of respiratory mechanics in the newborn.


Model Animal experimentation Sensitivity analysis Parameter identification