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Methods for Generating Hydrogel Particles for Protein Delivery

  • Emerging Trends in Biomaterials Research
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Abstract

Proteins represent a major class of therapeutic molecules with vast potential for the treatment of acute and chronic diseases and regenerative medicine applications. Hydrogels have long been investigated for their potential in carrying and delivering proteins. As compared to bulk hydrogels, hydrogel microparticles (microgels) hold promise in improving aspects of delivery owing to their less traumatic route of entry into the body and improved versatility. This review discusses common methods of fabricating microgels, including emulsion polymerization, microfluidic techniques, and lithographic techniques. Microgels synthesized from both natural and synthetic polymers are discussed, as are a series of microgels fashioned from environment-responsive materials.

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Acknowledgements

AJG is supported by the NIH (R01 AR062368, R01 AR062920, R21 EB020107) and the Juvenile Diabetes Research Foundation (2-SRA-2014-287-Q-R, 3-SRA-2015-38-Q-R). AL is supported by the NIH-sponsored Program on Graduate Training for Rationally Designed, Integrative Biomaterials (T32 EB006343).

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Authors and Affiliations

  1. Bioengineering Program, Georgia Institute of Technology, Atlanta, GA, USA

    Allen L. Liu

  2. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 2310 IBB Building, 315 Ferst Drive, Atlanta, GA, 30332, USA

    Allen L. Liu & Andrés J. García

  3. School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA, USA

    Allen L. Liu

  4. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA

    Andrés J. García

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Correspondence to Andrés J. García.

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Associate Editor Akhilesh K Gaharwar oversaw the review of this article.

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Liu, A.L., García, A.J. Methods for Generating Hydrogel Particles for Protein Delivery. Ann Biomed Eng 44, 1946–1958 (2016). https://doi.org/10.1007/s10439-016-1637-z

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