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Topology of Blood Transport in the Human Left Ventricle by Novel Processing of Doppler Echocardiography

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Abstract

Novel processing of Doppler-echocardiography data was used to study blood transport in the left ventricle (LV) of six patients with dilated cardiomyopathy and six healthy volunteers. Bi-directional velocity field maps in the apical long axis of the LV were reconstructed from color-Doppler echocardiography. Resulting velocity field data were used to perform trajectory-based computation of Lagrangian coherent structures (LCS). LCS were shown to reveal the boundaries of blood injected and ejected from the heart over multiple beats. This enabled qualitative and quantitative assessments of blood transport patterns and residence times in the LV. Quantitative assessments of stasis in the LV are reported, as well as characterization of LV vortex formations from E-wave and A-wave filling.

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Acknowledgments

This work was supported by the NIH National Heart, Lung and Blood Institute, award 5R21HL108268, and by grants (PIS09/02603 and RD06/0010) from the Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica, Instituto de Salud Carlos III–Ministerio de Economía y Competitividad, Spain.

Conflict of interest

The authors do not have any conflicts of interest in regards to this study.

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Authors and Affiliations

  1. Department of Mechanical, Materials and Aerospace Engineering, Illinois Institute of Technology, Chicago, IL, USA

    Sahar Hendabadi & Shawn C. Shadden

  2. Department of Cardiology, Hospital General Universitario Gregorio Marañón, Madrid, Spain

    Javier Bermejo, Yolanda Benito, Raquel Yotti & Francisco Fernández-Avilés

  3. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain

    Javier Bermejo, Yolanda Benito, Raquel Yotti & Francisco Fernández-Avilés

  4. Department of Mechanical and Aerospace Engineering, Institute for Engineering in Medicine, University of California San Diego, La Jolla, CA, USA

    Juan C. del Álamo

  5. Department of Mechanical Engineering, University of California, Berkeley, CA, 94720, USA

    Shawn C. Shadden

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  1. Sahar Hendabadi
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Correspondence to Shawn C. Shadden.

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Associate Editor Ender A. Finol oversaw the review of this article.

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Hendabadi, S., Bermejo, J., Benito, Y. et al. Topology of Blood Transport in the Human Left Ventricle by Novel Processing of Doppler Echocardiography. Ann Biomed Eng 41, 2603–2616 (2013). https://doi.org/10.1007/s10439-013-0853-z

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