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Determination of Critical Parameters in Platelet Margination

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Abstract

An investigation of margination dependence on hematocrit, platelet shape, and viscosity ratio of plasma to cytoplasm is presented. Whole blood is modeled as a suspension of deformable red blood cells (RBCs) and rigid platelets in a viscous liquid. The fluid phase is simulated using the lattice-Boltzmann method, the RBC membranes are modeled with a coarse-grained spectrin-link method, and the dynamics of rigid particles are updated using Newton’s equations of motion for axisymmetric shapes. The results emphasize that an increase in hematocrit increases the rate of margination. The viscosity ratio between the interior cytoplasm and suspending fluid can considerably alter the rate of margination. The aspect ratio of surrogate platelet particles influences the rate of margination as well. Spherical particles tend to migrate more quickly than disks. Highly viscous or rigid RBCs slow down margination.

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Abbreviations

RBC:

Red blood cell

LB:

Lattice-Boltzmann

SL:

Spectrin link

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Acknowledgments

The authors thank the National Science Foundation for use of the TeraGrid under grant number TG-CTS100012 and the Texas Advanced Computing Center for the use of Ranger. D.R. was funded by the United States Department of Defense through the ASEE SMART fellowship.

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Authors and Affiliations

  1. George W. Woodruff School of Mechanical Engineering, and The Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, 30332, USA

    Daniel A. Reasor Jr., Marmar Mehrabadi, David N. Ku & Cyrus K. Aidun

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  1. Daniel A. Reasor Jr.
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  2. Marmar Mehrabadi
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  4. Cyrus K. Aidun
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Correspondence to Cyrus K. Aidun.

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Associate Editor Konstantinos Konstantopoulos oversaw the review of this article.

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Reasor, D.A., Mehrabadi, M., Ku, D.N. et al. Determination of Critical Parameters in Platelet Margination. Ann Biomed Eng 41, 238–249 (2013). https://doi.org/10.1007/s10439-012-0648-7

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