Abstract
The objective of this study is to compare the safety and efficacy of laparoscopic ovarian drilling (LOD) utilizing monopolar versus bipolar needle in clomiphene-resistant polycystic ovaries (PCO) in infertile women. This study is a prospective randomized comparative diagnostic trial. The procedures were performed in an endoscopic unit of a tertiary care referral facility and university hospital. Eighty clomiphene-resistant PCO patients were randomly assigned by using a computerized random table into group A and group B for monopolar and bipolar LOD of 40 patients in each group, respectively. The intervention was LOD using monopolar or bipolar needle in groups A and B, respectively. The main outcome measures are resumption of regular menstruation, spontaneous ovulation, and pregnancy. Both groups showed a significant postoperative improvement of menstrual patterns and hormonal profiles if compared to preoperative levels without significant difference between both groups. Spontaneous ovulation resumed in 13 (32.5 %) and 25 (62 %), p = 0.007, while spontaneous pregnancy within 1 year after LOD occurred in 9 (22.5 %) and 18 (45 %) cases (p = 0.033) in both groups, respectively. Both monopolar and bipolar needles are effective tools for LOD in clomiphene citrate (CC)-resistant PCO infertile patients as a second-line therapy. Utilizing bipolar LOD is superior to monopolar LOD due to a significantly higher postoperative incidence of resumption of spontaneous ovulation and spontaneous pregnancy. Theoretical less adhesion formation following bipolar LOD requires a second-look laparoscopy study. In the meantime, spread of bipolar LOD should be encouraged.
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Change history
01 September 2022
Retraction Note: The Publisher has retracted this article. Concerns were raised about the statistical analysis of the results presented in Tables 2 and 3; the authors did not provide a response when asked about these concerns and stated that the raw data were no longer available. Assessment of the concerns by an independent expert concluded that there are inconsistencies in data analysis. The authors' institution was contacted with a request to investigate but did not respond. None of the authors have responded to correspondence from the Publisher about this retraction.
References
Ehrman DA (2005) Polycystic ovary syndrome. N Engl J Med 352:1223–1236
Flyckt RL, Goldberg JM (2011) Laparoscopic ovarian drilling for clomiphene-resistant polycystic ovary syndrome. Semin Reprod Med 29:138–146
Abu Hashim H, Al-Inany H, De Vos M, Tournaye H (2013) Three decades after Gjönnaess’s laparoscopic ovarian drilling for treatment of PCOS; what do we know? An evidence-based approach. Arch Gynecol Obstet 288(2):409–422
Lebbi E, Ben Tamemi R, Fadhlaoui A, Fekri A (2015) Ovarian drilling in PCOS: is it really useful? Frontiers in Surgery July 2:30
Farquhar C, Lilford RJ, Marjoribanks J, Vandekerckhove P (2007) Laparoscopic ‘drilling’ by diathermy or laser for ovulation induction in anovulatory polycystic ovary syndrome. Cochrane Database Syst Rev CD001122
Fernandez H, Watrelot A, Alby JD, Kadoch J, Gervaise A, deTayrac R, Frydman R (2004) Fertility after ovarian drilling by transvaginal fertiloscopy for treatment of polycystic ovary syndrome. J Am Assoc Gynecol Laparosc 11(3):374–378
Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group Human Reproduction 2003;19, 1, 41–47
Ahmed F.Amin, Diaa-Eldeen M. Abd El Aal, Atef M. Darwish, Abdel-Raheim M. A. Meki (2003) Evaluation of the impact of laparoscopic ovarian drilling on Doppler indices of ovarian stromal blood flow, serum vascular endothelial growth factor, and insulin-like growth factor-1 in women with polycystic ovary syndrome Fertility Sterility 79,4:938–4.
Nahuis MJ, Oude Lohuis E, Kose N, Bayram N, Hompes P, Oosterhuis GJ, Kaaijk EM, Cohlen BJ, Bossuyt PP, van der Veen F, Mol BW, van Wely M (2012) Long-term follow-up of laparoscopic electrocautery of the ovaries versus ovulation induction with recombinant FSH in clomiphene citrate-resistant women with polycystic ovary syndrome: an economic evaluation. Hum Reprod 27(12):3577–3582
Aflatoonian MD, Asgharnia M, Tayebi N (2007) Comparison of laparoscopic drilling by diathermy and laser for ovulation induction in clomiphene citrate-resistant women with polycystic ovary syndrome. Middle East Fertil Soc J 12(2):96–99
Gordts S, Campo R, Rombauts L, Brosens I (1998) Transvaginal hydrolaparoscopy as an outpatient procedure for infertility investigation. Hum Reprod 13:99–103
Darwish AM, Abdel Aleem MA, Ismail AM (2009) Risk of adhesions formation following microsurgical monopolar laparoscopic ovarian drilling: a comparative study. Gynecological Surgery 2, 6 (9) 2, 135–141
Chiesa-Montadou S, Rongieres C, Garbin O, Nisand I (2003) About two complications of ovarian drilling by fertiloscopy. Gynecol Obstet Fertil 31:844–846
Fernandez H, Faivre E, Gervaise A, Deffieux X (2010) Laparoscopic ovarian drilling using a 5-French bipolar energy probe. Fertil Steril 94:740–741
Amer SA, Li TC, Ledger WL (2009) The value of measuring anti-Mullerian hormone in women with anovulatory polycystic ovary syndrome undergoing laparoscopic ovarian diathermy. Hum Reprod 24:2760–2766
Dudhat A (2012) Laparoscopic ovarian drilling and its outcome. Int Collab Res Intern Med Public Health 4(12):2075–2083
Li TC, Saravelos H, Chow MS, Chisabingo R (1998) Factors affecting the outcome of laparoscopic ovarian drilling for polycystic ovarian syndrome in women with anovulatory infertility. Br J Obstet Gynaecol 105:338–344
Sharma M, Kriplani A, Agarwal N (2006) Laparoscopic bipolar versus unipolar ovarian drilling in infertile women with resistant. Surg J Gynecol Surg 2006 22(3):105–111
Amer SA, Li TC, Ledger WL (2004) Ovulation induction using laparoscopic ovarian drilling in women with polycystic ovarian syndrome: predictors of success. Hum Reprod 19:1719–1724
Merchant RN (1996) Treatment of polycystic ovary disease with laparoscopic low-watt bipolar electrocoagulation of the ovaries. J Am AssocGynecol Laparosc 3:503–508
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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This article has been retracted. Please see the retraction notice for more detail:https://doi.org/10.1186/s10397-022-01101-5
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Darwish, A.M., Metwally, A., Shaaban, M.M. et al. RETRACTED ARTICLE: Monopolar versus bipolar laparoscopic ovarian drilling in clomiphene-resistant polycystic ovaries (PCO): a preliminary study. Gynecol Surg 13, 179–185 (2016). https://doi.org/10.1007/s10397-016-0943-7
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DOI: https://doi.org/10.1007/s10397-016-0943-7