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A preliminary prospective study to compare the diagnostic performance of assist strain ratio versus manual strain ratio

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Abstract

Objectives

The objectives of this study were to demonstrate the non-inferiority of assist strain ratio (ASR)—a newly developed application tool—to manual strain ratio (MSR)—a currently available standard diagnostic tool—and to calculate the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of MSR and ASR.

Methods

Ninety-eight mass lesions in the mammary gland (30 malignant and 68 benign) were included in the study. Skilled physicians performed the elastography scanning by applying minimal vibration. MSRs were obtained and compared with ASRs calculated from the same elastography image to test the correlation between the two groups of data.

Results

Diagnostic performance of MSR at a cut-off of 5.0 showed a sensitivity of 84.4 %, a specificity of 80.4 %, an accuracy of 81.6 %, a PPV of 65.5 %, and an NPV of 92.1 %. Diagnostic performance of ASR at a cut-off of 5.0 showed a sensitivity of 74.4 %, a specificity of 84.3 %, an accuracy of 81.3 %, a PPV of 67.7 %, and an NPV of 88.2 %. The areas under the curve (AUCs) for MSR and ASR were found to be 0.885 and 0.875, respectively.

Conclusion

ASR demonstrated excellent diagnostic potential and was highly correlated with MSR performed by skilled physicians (r = 0.69, p < 0.05).

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Conflict of interest

Ultrasound software, which includes elastography and the newly developed ASR, was provided by Hitachi Aloka Medical, Ltd.

Ethical considerations

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008 (5). Informed consent was obtained from all patients for being included in the study.

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Authors and Affiliations

  1. Department of Senology, Tsukuba Medical Center Foundation, Tsukuba, Ibaraki, Japan

    Ei Ueno, Isamu Morishima & Takeshi Umemoto

  2. Total Health Evaluation Center Tsukuba, Tsukuba Medical Center Foundation, Tsukuba, Ibaraki, Japan

    Eriko Tohno

  3. Medical Systems Engineering Division 2, Hitachi Aloka Medical, Ltd., Kokubunji, Tokyo, Japan

    Koji Waki

Authors
  1. Ei Ueno
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  2. Eriko Tohno
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  3. Isamu Morishima
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  4. Takeshi Umemoto
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  5. Koji Waki
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Corresponding author

Correspondence to Ei Ueno.

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Ueno, E., Tohno, E., Morishima, I. et al. A preliminary prospective study to compare the diagnostic performance of assist strain ratio versus manual strain ratio. J Med Ultrasonics 42, 521–531 (2015). https://doi.org/10.1007/s10396-015-0633-5

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  • DOI: https://doi.org/10.1007/s10396-015-0633-5

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